4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate

Base Information

Chemical Name:4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate
CAS No.:1253955-20-2
Molecular Formula:C₃₃H₃₅N₃O₅
Molecular Weight:553.658
Hs Code.:

Synonyms:4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate

Suppliers and Price of 4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate

There total 11 articles about 4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253955-17-7
4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate

: 1253955-20-2
4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate

: 1253955-19-9
(S)-4-(3-((tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate

Guidance literature:: With Chiralpak AS-H column; In methanol; N,N-dimethyl-ethanamine; carbon dioxide; Resolution of racemate;

Reference yield:

: 4248-19-5
tert-butyl carbazate

: 1253955-20-2
4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate

: 1253955-19-9
(S)-4-(3-((tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / Dean-Stark; Reflux; Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Acidic conditions

2.2: -78 - -25 °C / Inert atmosphere

3.1: lithium hydroxide monohydrate; dihydrogen peroxide / water; tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

4.1: pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 24 h / 0 °C / Inert atmosphere

With pyridine; dmap; lithium hydroxide monohydrate; dihydrogen peroxide; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; In tetrahydrofuran; water; toluene;
DOI:10.1055/s-0037-1610310

Reference yield:

: 4-(2-methoxy-2-oxoethyl)benzyl 2,4-dimethylbenzoate

: 1253955-20-2
4-{3-[(tert-butoxycarbonyl)amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate

: 1253955-19-9
(S)-4-(3-((tert-butoxycarbonyl)amino)-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hydroxide monohydrate / water; acetonitrile; 1,4-dioxane / 0.67 h / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 1.25 h / 0 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Acidic conditions

4.2: -78 - -25 °C / Inert atmosphere

5.1: lithium hydroxide monohydrate; dihydrogen peroxide / water; tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

6.1: pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 24 h / 0 °C / Inert atmosphere

With pyridine; dmap; n-butyllithium; oxalyl dichloride; lithium hydroxide monohydrate; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;
DOI:10.1055/s-0037-1610310