Benzoic acid (2R,4S)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-4-[(S)-1-((1S,2R)-2-methoxy-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-butyl ester

Base Information

• Chemical Name: Benzoic acid (2R,4S)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-4-[(S)-1-((1S,2R)-2-methoxy-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-butyl ester
• CAS No.: 855315-59-2
• Molecular Formula: C₅₀H₆₉N₅O₉Si
• Molecular Weight: 912.211

Synonyms:Benzoic acid (2R,4S)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-4-[(S)-1-((1S,2R)-2-methoxy-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-butyl ester

Chemical Property of Benzoic acid (2R,4S)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-4-[(S)-1-((1S,2R)-2-methoxy-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid (2R,4S)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-4-[(S)-1-((1S,2R)-2-methoxy-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-butyl ester

There total 7 articles about Benzoic acid (2R,4S)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-4-[(S)-1-((1S,2R)-2-methoxy-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C65H79N5O11Si (855315-57-0) → Benzoic acid (2R,4S)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-4-[(S)-1-((1S,2R)-2-methoxy-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-butyl ester (855315-59-2)

Guidance literature:

With piperidine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tet.2005.03.058

Reference yield:

(2S,3R)-2-((S)-2-Amino-propionylamino)-3-methoxy-3-phenyl-propionic acid methyl ester → Benzoic acid (2R,4S)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-4-[(S)-1-((1S,2R)-2-methoxy-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-butyl ester (855315-59-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 4 h / 0 - 20 °C

2: trifluoroacetic acid / CH₂Cl₂

3: 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

4: piperidine / CH₂Cl₂ / 20 °C

With piperidine; 1-hydroxy-7-aza-benzotriazole; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tet.2005.03.058

Reference yield:

(2S,3R)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-3-methoxy-3-phenyl-propionic acid methyl ester (855315-41-2) → Benzoic acid (2R,4S)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-4-[(S)-1-((1S,2R)-2-methoxy-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-butyl ester (855315-59-2)

Guidance literature:

Multi-step reaction with 5 steps

1: trifluoroacetic acid / CH₂Cl₂

2: 80 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 4 h / 0 - 20 °C

3: trifluoroacetic acid / CH₂Cl₂

4: 1-hydroxy-7-azabenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

5: piperidine / CH₂Cl₂ / 20 °C

With piperidine; 1-hydroxy-7-aza-benzotriazole; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tet.2005.03.058

upstream raw materials:

C₆₅H₇₉N₅O₁₁Si

(2S,3R)-2-((S)-2-tert-Butoxycarbonylamino-propionylamino)-3-methoxy-3-phenyl-propionic acid methyl ester

(6S,9R,12S)-methyl 6-((R)-3-(benzoyloxy)-2-methylpropyl)-12-((R)-methoxy(phenyl)methyl)-2,2,5,9-tetramethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

(2S,3R)-2-Amino-3-methoxy-3-phenyl-propionic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 855315-59-2 Benzoic acid (2R,4S)-4-({(2S,3R)-2-amino-3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-propionyl}-methyl-amino)-4-[(S)-1-((1S,2R)-2-methoxy-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethylcarbamoyl]-2-methyl-butyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send