pentacyclo[4.2.0.0^2,5.0^3,8.0^4,7]octane-1-methanamine

Base Information

• Chemical Name: pentacyclo[4.2.0.0^2,5.0^3,8.0^4,7]octane-1-methanamine
• CAS No.: 150234-60-9
• Molecular Formula: C₉H₁₁N
• Molecular Weight: 133.193
• Mol file: 150234-60-9.mol

Synonyms:pentacyclo[4.2.0.0^2,5.0^3,8.0^4,7]octane-1-methanamine

Chemical Property of pentacyclo[4.2.0.0^2,5.0^3,8.0^4,7]octane-1-methanamine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Cuban-1-ylmethanamine hydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pentacyclo[4.2.0.0^2,5.0^3,8.0^4,7]octane-1-methanamine

There total 5 articles about pentacyclo[4.2.0.0^2,5.0^3,8.0^4,7]octane-1-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1-cubanecarboxamide (119696-06-9) → pentacyclo[4.2.0.02,5.03,8.04,7]octane-1-methanamine (150234-60-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 16h; Reflux;

DOI:10.1016/j.bmcl.2013.12.087

Reference yield:

cubane-1-carboxylic acid (53578-15-7) → pentacyclo[4.2.0.02,5.03,8.04,7]octane-1-methanamine (150234-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride / 0.33 h / Ambient temperature

2: NH₃ (gas) / CH₂Cl₂ / 0.33 h

3: LiAlH₄ / tetrahydrofuran / 15 h / Heating

With lithium aluminium tetrahydride; oxalyl dichloride; ammonia; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm9606249

Reference yield:

Cubancarbonsaeurechlorid (60462-14-8) → pentacyclo[4.2.0.02,5.03,8.04,7]octane-1-methanamine (150234-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃ (gas) / CH₂Cl₂ / 0.33 h

2: LiAlH₄ / tetrahydrofuran / 15 h / Heating

With lithium aluminium tetrahydride; ammonia; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm9606249

upstream raw materials:

1-cubanecarboxamide

cubane-1-carboxylic acid

Cubancarbonsaeurechlorid

4-iodopentacyclo[4.2.0.0^2,5.0^3,8.0^4,7]octane-1-carboxylic acid

Downstream raw materials:

N-cuban-1-ylmethyl-(2-chloro-5-methoxy)-benzamide

N-cuban-1-ylmethyl-2-fluoro-benzamide

N-cuban-1-ylmethyl-4-fluoro-benzamide