N-(3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide

Base Information

Chemical Name:N-(3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide
CAS No.:1438841-57-6
Molecular Formula:C₃₁H₄₂N₆O₂Si
Molecular Weight:558.799
Hs Code.:

Synonyms:N-(3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide

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Chemical Property of N-(3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide

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Technology Process of N-(3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide

There total 4 articles about N-(3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1438841-56-5
N-(3-(5-amino-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1438841-57-6
N-(3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm4000215

Reference yield:

: 78887-39-5
3-Acetamidophenylboronic acid

: 1438841-57-6
N-(3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C

1.2: 3 h / Inert atmosphere; Reflux

2.1: ethanol; iron; ammonium chloride / water / 0.75 h / Reflux

3.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C

With ethanol; sodium tris(acetoxy)borohydride; iron; sodium hydride; ammonium chloride; acetic acid; In dichloromethane; water; N,N-dimethyl-formamide; 1.2: |Suzuki Coupling;
DOI:10.1021/jm4000215

Reference yield:

: 1438841-55-4
N-(3-(6-(1-methyl-1H-pyrazol-4-yl)-5-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide

: 1438841-57-6
N-(3-(5-(cyclohexylamino)-6-(1-methyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol; iron; ammonium chloride / water / 0.75 h / Reflux

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C

With ethanol; sodium tris(acetoxy)borohydride; iron; ammonium chloride; acetic acid; In dichloromethane; water;
DOI:10.1021/jm4000215