3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenyl sulfonyl)-1H-pyrrolo[2,3-b]pyridine

Base Information

• Chemical Name: 3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenyl sulfonyl)-1H-pyrrolo[2,3-b]pyridine
• CAS No.: 1262293-72-0
• Molecular Formula: C₁₉H₁₆N₄O₅S₂
• Molecular Weight: 444.492
• Mol file: 1262293-72-0.mol

Synonyms:3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenyl sulfonyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property of 3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenyl sulfonyl)-1H-pyrrolo[2,3-b]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenyl sulfonyl)-1H-pyrrolo[2,3-b]pyridine

There total 3 articles about 3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenyl sulfonyl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-(6-methoxy-2-(methylthio)pyrimidin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (1262293-71-9) → 3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenyl sulfonyl)-1H-pyrrolo[2,3-b]pyridine (1262293-72-0)

Guidance literature:

With Oxone; In ethyl acetate; at 77 ℃; for 48h;

Reference yield:

1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine (886547-94-0) → 3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenyl sulfonyl)-1H-pyrrolo[2,3-b]pyridine (1262293-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 0.33 h / 85 °C / Inert atmosphere

2: OXONE_.(R). / ethyl acetate / 48 h / 77 °C

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine (89466-42-2) → 3-(6-methoxy-2-(methylsulfonyl)pyrimidin-4-yl)-1-(phenyl sulfonyl)-1H-pyrrolo[2,3-b]pyridine (1262293-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 0.33 h / 85 °C / Inert atmosphere

2: OXONE_.(R). / ethyl acetate / 48 h / 77 °C

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

3-(6-methoxy-2-(methylthio)pyrimidin-4-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine

1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

N-cyclohexyl-4-methoxy-6-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine

2-anilino-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4(3H)-one

3-((4-methoxy-6-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-ylamino)methyl)phenol

2-phenyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4(3H)-one