2-chloro-4-(3-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol

Base Information

Chemical Name:2-chloro-4-(3-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol
CAS No.:406196-96-1
Molecular Formula:C₁₉H₁₄Cl₂N₄O
Molecular Weight:385.252
Hs Code.:

Synonyms:2-chloro-4-(3-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol

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Chemical Property of 2-chloro-4-(3-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol

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Technology Process of 2-chloro-4-(3-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol

There total 4 articles about 2-chloro-4-(3-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 406196-95-0
[2-chloro-4-(3-chlorophenyl)-6-quinazolinyl](1-methyl-1H-imidazol-5-yl)methanone

: 406196-96-1
2-chloro-4-(3-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -70 ℃; for 3.5h;
DOI:10.1016/j.ejmech.2006.12.007

Reference yield:

: 6-bromo-2-methoxy-4-(3-chlorophenyl)quinazoline

: 406196-96-1
2-chloro-4-(3-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 27 percent / Et₃N / Pd(PPh₃)4 / dioxane / 18 h / 100 °C / 3750.38 Torr

2.1: 59 percent / POCl₃ / dimethylformamide / 4 h / 80 °C

3.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -70 °C

3.2: 2.46 g / tetrahydrofuran; hexane / 0.5 h / -70 - 20 °C

4.1: 86 percent / DIBAL-H / toluene; tetrahydrofuran / 3.5 h / -70 °C

With n-butyllithium; diisobutylaluminium hydride; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2006.12.007

Reference yield:

: 406196-93-8
4-(3-chlorophenyl)-N,2-dimethoxy-N-methyl-6-quinazolinecarboxamide

: 406196-96-1
2-chloro-4-(3-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 59 percent / POCl₃ / dimethylformamide / 4 h / 80 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -70 °C

2.2: 2.46 g / tetrahydrofuran; hexane / 0.5 h / -70 - 20 °C

3.1: 86 percent / DIBAL-H / toluene; tetrahydrofuran / 3.5 h / -70 °C

With n-butyllithium; diisobutylaluminium hydride; trichlorophosphate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2006.12.007