4-Thiazolecarboxaldehyde, 5-(1-methylethyl)- (9CI)

Base Information

Chemical Name:4-Thiazolecarboxaldehyde, 5-(1-methylethyl)- (9CI)
CAS No.:261710-82-1
Molecular Formula:C7H9 N O S
Molecular Weight:155.21746
Hs Code.:
Mol file:261710-82-1.mol

Synonyms:4-Thiazolecarboxaldehyde, 5-(1-methylethyl)- (9CI)

Suppliers and Price of 4-Thiazolecarboxaldehyde, 5-(1-methylethyl)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-Thiazolecarboxaldehyde, 5-(1-methylethyl)- (9CI)

Chemical Property:

Boiling Point:255.3±28.0 °C(Predicted)
PKA:0.89±0.10(Predicted)
PSA：58.20000
Density:1.159±0.06 g/cm3(Predicted)
LogP:2.07900

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Thiazolecarboxaldehyde, 5-(1-methylethyl)- (9CI)

There total 1 articles about 4-Thiazolecarboxaldehyde, 5-(1-methylethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 81569-26-8
5-isopropyl-thiazole-4-carboxylic acid methyl ester

: 261710-82-1
5-isopropyl-thiazole-4-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; for 1.5h;
DOI:10.1021/jm0003844

Reference yield:

: 261710-82-1
5-isopropyl-thiazole-4-carbaldehyde

: 3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-isopropyl-6-[2-(5-isopropyl-thiazol-4-yl)-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: K₂CO₃ / acetonitrile; H₂O / 18 h / 20 °C

2.1: H₂ / 5percent Pd/BaSO₄ / tetrahydrofuran / 26 h / 1654.92 Torr

3.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

3.2: n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

3.3: tetrahydrofuran / 1.5 h / 0 - 20 °C

4.1: 1 N aq. NaOH / tetrahydrofuran / 1 h

4.2: aq. HCl / pH 4.5

5.1: K₂CO₃ / dimethylformamide / 20 °C

With sodium hydroxide; hydrogen; sodium hydride; potassium carbonate; 5percent Pd/BaSO₄; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0003844