4-Benzyloxycarbonylamino-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester; hydrochloride

Base Information

Chemical Name:4-Benzyloxycarbonylamino-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester; hydrochloride
CAS No.:139131-85-4
Molecular Formula:C₂₀H₁₉N₃O₄*ClH
Molecular Weight:401.849
Hs Code.:

Synonyms:4-Benzyloxycarbonylamino-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester; hydrochloride

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Chemical Property of 4-Benzyloxycarbonylamino-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester; hydrochloride

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Technology Process of 4-Benzyloxycarbonylamino-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester; hydrochloride

There total 5 articles about 4-Benzyloxycarbonylamino-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 139131-84-3
Methyl 5-<(Benzyloxycabonyl)amino>-3-(tert-butyloxycarbonyl)-1,2-dihydro-3H-pyrrolo<3,2-e>indole-7-carboxylate

: 139131-85-4
4-Benzyloxycarbonylamino-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 23 ℃; for 1h;
DOI:10.1021/jo00030a042

Reference yield:

: 107474-66-8
methyl 3-(tert-butyloxycarbonyl)-1,2-dihydro-3H-pyrrolo<3,2-e>indole-7-carboxylate

: 139131-85-4
4-Benzyloxycarbonylamino-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / HNO₃ / nitromethane / 1.5 h / 0 °C

2: 93 percent / H₂ / 10percent Pd-C / tetrahydrofuran / 12 h / 760 Torr

3: 83 percent / K₂CO₃ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) 23 deg C, 1 h

4: 100 percent / HCl / ethyl acetate / 1 h / 23 °C

With hydrogenchloride; hydrogen; nitric acid; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; nitromethane; ethyl acetate;
DOI:10.1021/jo00030a042

Reference yield:

: 139131-83-2
Methyl 3-(tert-Butyloxycarbonyl)-5-nitro-1,2-dihydro-3H-pyrrolo<3,2-e>indole-7-carboxylate

: 139131-85-4
4-Benzyloxycarbonylamino-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / H₂ / 10percent Pd-C / tetrahydrofuran / 12 h / 760 Torr

2: 83 percent / K₂CO₃ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) 23 deg C, 1 h

3: 100 percent / HCl / ethyl acetate / 1 h / 23 °C

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jo00030a042