3-(3-chloro-4-fluorobenzyl)-5-methoxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione

Base Information

Chemical Name:3-(3-chloro-4-fluorobenzyl)-5-methoxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione
CAS No.:1202013-46-4
Molecular Formula:C₂₁H₂₀ClFN₄O₄
Molecular Weight:446.866
Hs Code.:

Synonyms:3-(3-chloro-4-fluorobenzyl)-5-methoxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione

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Chemical Property of 3-(3-chloro-4-fluorobenzyl)-5-methoxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione

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Technology Process of 3-(3-chloro-4-fluorobenzyl)-5-methoxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione

There total 14 articles about 3-(3-chloro-4-fluorobenzyl)-5-methoxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202013-44-2
3-(3-chloro-4-fluorobenzyl)-5-methoxy-8-[(methyl{4-[(methylsulfonyl)oxy]butyl}amino)carbonyl]-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-6-yl methanesulfonate

: 1202013-46-4
3-(3-chloro-4-fluorobenzyl)-5-methoxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

Reference yield:

: 709666-23-9
ethyl 3-[(tert-butoxycarbonyl)amino]-5-methoxyisonicotinate

: 1202013-46-4
3-(3-chloro-4-fluorobenzyl)-5-methoxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione

Guidance literature:: Multi-step reaction with 14 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: ethanol / 48 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

4: peracetic acid; sodium acetate; acetic acid / 12 h / 20 °C

5: 0.33 h / 130 °C / Microwave irradiation

6: water; sodium hydroxide / methanol / 2 h / 20 °C

7: 2,6-dimethylpyridine; dmap / dichloromethane / 14 h / 20 °C

8: N-ethyl-N,N-diisopropylamine / palladium diacetate / dimethyl sulfoxide / 24 h / 80 °C / 15514.9 Torr

9: urea hydrogen peroxide adduct / methyltrioxorhenium(VII) / methanol; chloroform / 168 h / 20 °C

10: 2 h / 130 °C

11: water; sodium hydroxide / methanol / 3 h / 40 °C

12: 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 20 °C

13: triethylamine / dichloromethane / 0 °C

14: caesium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; peracetic acid; dmap; 1-hydroxy-7-aza-benzotriazole; water; sodium acetate; urea hydrogen peroxide adduct; caesium carbonate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; palladium diacetate; methyltrioxorhenium(VII); In methanol; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1202013-26-0
3-(3-chloro-4-fluorobenzyl)-5-methoxypyrido[3,4-d]pyrimidin-4(3H)-one-7-oxide

: 1202013-46-4
3-(3-chloro-4-fluorobenzyl)-5-methoxy-12-methyl-9,10,11,12-tetrahydro-3H-pyridazino[4',5':3,4]pyrido[1,2-a][1,4]diazocine-4,6,13(8H)-trione

Guidance literature:: Multi-step reaction with 10 steps

1: 0.33 h / 130 °C / Microwave irradiation

2: water; sodium hydroxide / methanol / 2 h / 20 °C

3: 2,6-dimethylpyridine; dmap / dichloromethane / 14 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / palladium diacetate / dimethyl sulfoxide / 24 h / 80 °C / 15514.9 Torr

5: urea hydrogen peroxide adduct / methyltrioxorhenium(VII) / methanol; chloroform / 168 h / 20 °C

6: 2 h / 130 °C

7: water; sodium hydroxide / methanol / 3 h / 40 °C

8: 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 20 °C

9: triethylamine / dichloromethane / 0 °C

10: caesium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; dmap; 1-hydroxy-7-aza-benzotriazole; water; urea hydrogen peroxide adduct; caesium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium diacetate; methyltrioxorhenium(VII); In methanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;