2-(3,4-bis(methoxymethoxy)phenyl)-6,8-dibromo-3-hydroxy-4H-chromen-4-one

Base Information

• Chemical Name: 2-(3,4-bis(methoxymethoxy)phenyl)-6,8-dibromo-3-hydroxy-4H-chromen-4-one
• CAS No.: 1609456-21-4
• Molecular Formula: C₁₉H₁₆Br₂O₇
• Molecular Weight: 516.14

Synonyms:2-(3,4-bis(methoxymethoxy)phenyl)-6,8-dibromo-3-hydroxy-4H-chromen-4-one

Chemical Property of 2-(3,4-bis(methoxymethoxy)phenyl)-6,8-dibromo-3-hydroxy-4H-chromen-4-one

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Technology Process of 2-(3,4-bis(methoxymethoxy)phenyl)-6,8-dibromo-3-hydroxy-4H-chromen-4-one

There total 3 articles about 2-(3,4-bis(methoxymethoxy)phenyl)-6,8-dibromo-3-hydroxy-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(E)-3-(3,4-bis(methoxymethoxy)phenyl)-1-(3,5-dibromo-2-hydroxyphenyl)prop-2-en-1-one (1609456-19-0) → 2-(3,4-bis(methoxymethoxy)phenyl)-6,8-dibromo-3-hydroxy-4H-chromen-4-one (1609456-21-4)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In 1,4-dioxane; ethanol; at 0 ℃; for 12h;

DOI:10.1016/j.tet.2014.04.022

Reference yield:

3,4-bis-methoxymethoxy-benzaldehyde (6515-06-6) → 2-(3,4-bis(methoxymethoxy)phenyl)-6,8-dibromo-3-hydroxy-4H-chromen-4-one (1609456-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 20 °C

2: sodium hydroxide; dihydrogen peroxide / ethanol; 1,4-dioxane / 12 h / 0 °C

With dihydrogen peroxide; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; ethanol; 1: |Claisen-Schmidt Condensation / 2: |Algar-Flynn-Olyamada Reaction;

DOI:10.1016/j.tet.2014.04.022

Reference yield:

3,5-dibromo-2-hydroxyacetophenone (22362-66-9) → 2-(3,4-bis(methoxymethoxy)phenyl)-6,8-dibromo-3-hydroxy-4H-chromen-4-one (1609456-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 20 °C

2: sodium hydroxide; dihydrogen peroxide / ethanol; 1,4-dioxane / 12 h / 0 °C

With dihydrogen peroxide; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; ethanol; 1: |Claisen-Schmidt Condensation / 2: |Algar-Flynn-Olyamada Reaction;

DOI:10.1016/j.tet.2014.04.022

upstream raw materials:

3,4-bis-methoxymethoxy-benzaldehyde

(E)-3-(3,4-bis(methoxymethoxy)phenyl)-1-(3,5-dibromo-2-hydroxyphenyl)prop-2-en-1-one

3,5-dibromo-2-hydroxyacetophenone

Downstream raw materials:

2-(3,4-bis(methoxymethoxy)phenyl)-6-amino-3-hydroxy-4H-chromen-4-one

6-amino-3-hydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one

6,8-dibromo-3-hydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one

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