(4-chlorophenyl)(4-(4-chlorophenyl)-1-(prop-2-ynyl)-1H-imidazol-2-yl)methanone

Base Information

• Chemical Name: (4-chlorophenyl)(4-(4-chlorophenyl)-1-(prop-2-ynyl)-1H-imidazol-2-yl)methanone
• CAS No.: 1384177-44-9
• Molecular Formula: C₁₉H₁₂Cl₂N₂O
• Molecular Weight: 355.223
• Mol file: 1384177-44-9.mol

Synonyms:(4-chlorophenyl)(4-(4-chlorophenyl)-1-(prop-2-ynyl)-1H-imidazol-2-yl)methanone

Chemical Property of (4-chlorophenyl)(4-(4-chlorophenyl)-1-(prop-2-ynyl)-1H-imidazol-2-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-chlorophenyl)(4-(4-chlorophenyl)-1-(prop-2-ynyl)-1H-imidazol-2-yl)methanone

There total 2 articles about (4-chlorophenyl)(4-(4-chlorophenyl)-1-(prop-2-ynyl)-1H-imidazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4‐chlorophenyl)[4‐(4‐chlorophenyl)‐1H‐imidazol‐2‐yl]methanone + propargyl bromide (106-96-7) → (4-chlorophenyl)(4-(4-chlorophenyl)-1-(prop-2-ynyl)-1H-imidazol-2-yl)methanone (1384177-44-9)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 20 ℃; for 1h;

DOI:10.1055/s-0031-1290979

Reference yield:

para-chloroacetophenone (99-91-2) → (4-chlorophenyl)(4-(4-chlorophenyl)-1-(prop-2-ynyl)-1H-imidazol-2-yl)methanone (1384177-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: selenium(IV) oxide / 1,4-dioxane / 0.05 h / 120 °C / Microwave irradiation

1.2: 0.5 h

2.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 1 h / 20 °C

With selenium(IV) oxide; tetrabutylammomium bromide; sodium hydroxide; In 1,4-dioxane; water; toluene;

DOI:10.1055/s-0031-1290979

Reference yield: 92.0%

(4-chlorophenyl)(4-(4-chlorophenyl)-1-(prop-2-ynyl)-1H-imidazol-2-yl)methanone (1384177-44-9) → (4-chlorophenyl)[4-(4-chlorophenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanol (1384177-17-6)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1021/jo300855f

upstream raw materials:

propargyl bromide

para-chloroacetophenone

Downstream raw materials:

2,8-bis(4-chlorophenyl)-6-(pyrrolidin-1-yl)imidazo[1,2-a]pyridine

2,8-bis(4-chlorophenyl)-N,N-diethylimidazo[1,2-a]pyridin-6-amine

2,9-bis(4-chlorophenyl)-8-tosyl-8,9-dihydro-5H-imidazo[1,2-a][1,4]-diazepin-7(6H)-one

2,9-bis(4-chlorophenyl)-8-(methylsulfonyl)-8,9-dihydro-5H-imidazo[1,2-a][1,4]-diazepin-7(6H)-one