BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Base Information

Chemical Name:BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide
CAS No.:113238-39-4
Molecular Formula:C₄₀H₆₁N₇O₇S
Molecular Weight:784.033
Hs Code.:

BOC-PheΨ<COCH2S>Gly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Synonyms:BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Suppliers and Price of BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

There total 5 articles about BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 114343-86-1
2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>thio>acetic acid

: 136735-33-6
H-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide dihydrochloride

: 113238-39-4
BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 14h; Ambient temperature;
DOI:10.1021/jm00115a016

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 113238-39-4
BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: Multi-step reaction with 5 steps

1: N-methylmorpholine (NMM) / ethyl acetate / 0.17 h / -10 °C

2: diethyl ether / 3 h / Ambient temperature

3: 47percent aq. HBr / dioxane / 1 h / 0 °C

4: 1.) NaOMe / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 1 h

5: 76 percent / N-NMM, 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With 4-methyl-morpholine; hydrogen bromide; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a016

Reference yield:

: 68709-71-7
tert-butyl 4-bromo-3-oxo-1-phenylbutan-2-ylcarbamate

: 113238-39-4
BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaOMe / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 1 h

2: 76 percent / N-NMM, 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00115a016