2-((1R,2S)-1,2,5,5-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol

Base Information

• Chemical Name: 2-((1R,2S)-1,2,5,5-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol
• CAS No.: 72853-85-1
• Molecular Formula: C₂₁H₃₀O₂
• Molecular Weight: 314.468
• Mol file: 72853-85-1.mol

Synonyms:2-((1R,2S)-1,2,5,5-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol

Chemical Property of 2-((1R,2S)-1,2,5,5-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((1R,2S)-1,2,5,5-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol

There total 13 articles about 2-((1R,2S)-1,2,5,5-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C33H58O2Si2 (1395881-52-3) → 2-((1R,2S)-1,2,5,5-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol (72853-85-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/ol301715u DOI:10.1021/ol301715u

Reference yield: 59.0%

Acetic acid 4-acetoxy-2-((1R,2S)-1,2,5,5-tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-phenyl ester (72853-84-0) → 2-((1R,2S)-1,2,5,5-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol (72853-85-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 0.333333h; Ambient temperature;

DOI:10.1021/jo01296a019

Reference yield: 20.0%

Aureol (72853-81-7) → (+)-5-epi-aureol (127707-56-6) + 2-((1R,2S)-1,2,5,5-Tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol (72853-85-1)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 0.5h; Heating;

upstream raw materials:

Aureol

Acetic acid 4-acetoxy-2-((1R,2S)-1,2,5,5-tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalen-1-ylmethyl)-phenyl ester

C₂₃H₃₄O

C₁₅H₂₄O

Downstream raw materials:

(1R,2S)-1-(2,5-Dimethoxy-benzyl)-1,2,5,5-tetramethyl-1,2,3,4,5,6,7,8-octahydro-naphthalene

Aureol