7-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylic acid

Base Information

Chemical Name:7-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylic acid
CAS No.:1356110-97-8
Molecular Formula:C₂₅H₂₇FN₂O₆S
Molecular Weight:502.564
Hs Code.:

Synonyms:7-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylic acid

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Chemical Property of 7-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylic acid

Chemical Property:

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Technology Process of 7-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylic acid

There total 11 articles about 7-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356112-56-5
methyl 7-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonyl-amino]-4H-furo[2,3-c]chromene-6-carboxylate

: 1356110-97-8
7-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In 1,4-dioxane; at 90 ℃; for 20h;

Reference yield:

: 681247-11-0
methyl 6-amino-3-bromo-2-hydroxybenzoate

: 1356110-97-8
7-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 65 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 1 h

2.2: 2 h

3.1: ethanol; sodium tetrahydroborate / 0.25 h

4.1: sodium hydroxide; water / methanol / 1.5 h / 45 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C

5.2: 1 h

6.1: hydrogenchloride / 1,4-dioxane / 1.5 h

6.2: 18 h

7.1: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; dimethyl sulfoxide / 0.75 h / 150 °C / Microwave irradiation; Sealed vial; Inert atmosphere

8.1: hydrogen; formic acid / palladium(II) hydroxide / ethanol / Inert atmosphere

9.1: water; lithium hydroxide / 1,4-dioxane / 20 h / 90 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; formic acid; ethanol; carbon tetrabromide; water; hydrogen; caesium carbonate; triethylamine; triphenylphosphine; sodium hydroxide; lithium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium(II) hydroxide; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 681247-87-0,681247-88-1
N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)-amine

: 1356110-97-8
7-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-4H-furo[2,3-c]chromene-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tri tert-butylphosphoniumtetrafluoroborate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; dimethyl sulfoxide / 0.75 h / 150 °C / Microwave irradiation; Sealed vial; Inert atmosphere

2: hydrogen; formic acid / palladium(II) hydroxide / ethanol / Inert atmosphere

3: water; lithium hydroxide / 1,4-dioxane / 20 h / 90 °C

With formic acid; water; hydrogen; lithium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium(II) hydroxide; In 1,4-dioxane; ethanol; dimethyl sulfoxide;