(2RS,5SR,9RS,10SR)-9-tert-butyldiphenylsilyloxy-2-(3-hydroxypropen-2-yl)-6,10-dimethylspiro<4.5>dec-6-en-8-one ethylene dithioacetal

Base Information

Chemical Name:(2RS,5SR,9RS,10SR)-9-tert-butyldiphenylsilyloxy-2-(3-hydroxypropen-2-yl)-6,10-dimethylspiro<4.5>dec-6-en-8-one ethylene dithioacetal
CAS No.:111675-34-4
Molecular Formula:C₃₃H₄₄O₂S₂Si
Molecular Weight:564.929
Hs Code.:

Synonyms:(2RS,5SR,9RS,10SR)-9-tert-butyldiphenylsilyloxy-2-(3-hydroxypropen-2-yl)-6,10-dimethylspiro<4.5>dec-6-en-8-one ethylene dithioacetal

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Chemical Property of (2RS,5SR,9RS,10SR)-9-tert-butyldiphenylsilyloxy-2-(3-hydroxypropen-2-yl)-6,10-dimethylspiro<4.5>dec-6-en-8-one ethylene dithioacetal

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Technology Process of (2RS,5SR,9RS,10SR)-9-tert-butyldiphenylsilyloxy-2-(3-hydroxypropen-2-yl)-6,10-dimethylspiro<4.5>dec-6-en-8-one ethylene dithioacetal

There total 10 articles about (2RS,5SR,9RS,10SR)-9-tert-butyldiphenylsilyloxy-2-(3-hydroxypropen-2-yl)-6,10-dimethylspiro<4.5>dec-6-en-8-one ethylene dithioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 111675-33-3
(2RS,5SR,9RS,10SR)-9-tert-butyldiphenylsilyloxy-2-(1-ethoxycarbonylvinyl)-6,10-dimethylspiro<4.5>dec-6-en-8-one ethylene dithioacetal

: 111675-34-4
(2RS,5SR,9RS,10SR)-9-tert-butyldiphenylsilyloxy-2-(3-hydroxypropen-2-yl)-6,10-dimethylspiro<4.5>dec-6-en-8-one ethylene dithioacetal

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -70 ℃; for 0.0833333h;

Reference yield:

: 101415-96-7,101470-76-2
(2RS,5RS,9SR,10RS)-9-hydroxy-6,10-dimethyl-2-pivaloyloxyspiro<4.5>dec-6-en-8-one

: 111675-34-4
(2RS,5SR,9RS,10SR)-9-tert-butyldiphenylsilyloxy-2-(3-hydroxypropen-2-yl)-6,10-dimethylspiro<4.5>dec-6-en-8-one ethylene dithioacetal

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / imidazole / dimethylformamide / 12 h / 50 °C

2: 66 percent / BF₃*Et₂O / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 79 percent / methyllithium / diethyl ether / 0.33 h / 0 °C

4: pyridine / 4 h / 0 °C

5: 1.) NaH / 1.) DME, 2.) DME, reflux, 7 h

6: 80 percent / KOH / ethanol / 12 h / Ambient temperature

7: 1.) diethylamine, 2.) NaOAc / 1.) reflux, 20 min, 2.) AcOH, reflux, 15 min

8: 89 percent / diisobutylaluminum hydride / toluene / 0.08 h / -70 °C

With pyridine; 1H-imidazole; potassium hydroxide; boron trifluoride diethyl etherate; methyllithium; sodium acetate; sodium hydride; diisobutylaluminium hydride; diethylamine; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 111675-32-2
2-[(8S,10R,13S,14R)-14-(tert-Butyl-diphenyl-silanyloxy)-7,13-dimethyl-1,4-dithia-dispiro[4.2.4.2]tetradec-6-en-10-yl]-malonic acid monoethyl ester

: 111675-34-4
(2RS,5SR,9RS,10SR)-9-tert-butyldiphenylsilyloxy-2-(3-hydroxypropen-2-yl)-6,10-dimethylspiro<4.5>dec-6-en-8-one ethylene dithioacetal

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) diethylamine, 2.) NaOAc / 1.) reflux, 20 min, 2.) AcOH, reflux, 15 min

2: 89 percent / diisobutylaluminum hydride / toluene / 0.08 h / -70 °C

With sodium acetate; diisobutylaluminium hydride; diethylamine; In toluene;