Boc-val-Orn(Z)-δAva-OMe

Base Information

• Chemical Name: Boc-val-Orn(Z)-δAva-OMe
• CAS No.: 103309-82-6
• Molecular Formula: C₂₉H₄₆N₄O₈
• Molecular Weight: 578.706
• Mol file: 103309-82-6.mol

Synonyms:Boc-val-Orn(Z)-δAva-OMe

Chemical Property of Boc-val-Orn(Z)-δAva-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-val-Orn(Z)-δAva-OMe

There total 2 articles about Boc-val-Orn(Z)-δAva-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-aminopentanoic acid methyl ester hydrochloride (29840-56-0) + Boc-Val-Orn(Z)-azid (74862-98-9) → Boc-val-Orn(Z)-δAva-OMe (103309-82-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 72h; Yield given;

DOI:10.1246/bcsj.59.185

Reference yield:

Boc-Val-Orn(Z)-NH-NH2 (5519-59-5) → Boc-val-Orn(Z)-δAva-OMe (103309-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1: isopentyl nitrite, 2.9M HCl / dioxane; dimethylformamide / 0.08 h / -30 °C

2: Et₃N / dimethylformamide / 72 h / 0 °C

With hydrogenchloride; triethylamine; isopentyl nitrite; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.59.185

Reference yield: 92.1%

Boc-val-Orn(Z)-δAva-OMe (103309-82-6) → Boc-Val-Orn(Z)-δAva-NHNH2 (103290-17-1)

Guidance literature:

With hydrazine hydrate; In methanol; Ambient temperature;

DOI:10.1246/bcsj.59.185

upstream raw materials:

5-aminopentanoic acid methyl ester hydrochloride

Boc-Val-Orn(Z)-azid

Boc-Val-Orn(Z)-NH-NH₂

Downstream raw materials:

Boc-Val-Orn(Z)-δAva-NHNH2

cyclo-(Val-Orn(Z)-δAva-Pro)2