N-(N-benzhydrylidene-2-aza-glycinyl)-L-phenylalanine tert-butyl ester

Base Information

• Chemical Name: N-(N-benzhydrylidene-2-aza-glycinyl)-L-phenylalanine tert-butyl ester
• CAS No.: 1416342-89-6
• Molecular Formula: C₂₇H₂₉N₃O₃
• Molecular Weight: 443.546
• Mol file: 1416342-89-6.mol

Synonyms:N-(N-benzhydrylidene-2-aza-glycinyl)-L-phenylalanine tert-butyl ester

Chemical Property of N-(N-benzhydrylidene-2-aza-glycinyl)-L-phenylalanine tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N-benzhydrylidene-2-aza-glycinyl)-L-phenylalanine tert-butyl ester

There total 2 articles about N-(N-benzhydrylidene-2-aza-glycinyl)-L-phenylalanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzophenone hydrazone (1178561-47-1) + L-phenylalanine tert-butyl ester hydrochloride (15100-75-1,75898-47-4) → N-(N-benzhydrylidene-2-aza-glycinyl)-L-phenylalanine tert-butyl ester (1416342-89-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1139/v2012-070

Reference yield:

1-(2,5-dioxopyrrolidin-1-yl)-N'-(diphenylmethylidene) carbazate (1513924-93-0) + L-phenylalanine tert-butyl ester hydrochloride (15100-75-1,75898-47-4) → N-(N-benzhydrylidene-2-aza-glycinyl)-L-phenylalanine tert-butyl ester (1416342-89-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

DOI:10.1002/psc.2572

Reference yield: 73.0%

N-(N-benzhydrylidene-2-aza-glycinyl)-L-phenylalanine tert-butyl ester (1416342-89-6) + propargyl bromide (106-96-7) → N-(N-benzhydrylidene-2-aza-2-propargylglycinyl)-L-phenylalanine tert-butyl ester (1416342-94-3)

Guidance literature:

N-(N-benzhydrylidene-2-aza-glycinyl)-L-phenylalanine tert-butyl ester; With tetraethylammonium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 0.5h;

propargyl bromide; In tetrahydrofuran; water; toluene; at 60 ℃; for 3h; Microwave irradiation;

DOI:10.1002/psc.2572

upstream raw materials:

benzophenone hydrazone

L-phenylalanine tert-butyl ester hydrochloride

1-(2,5-dioxopyrrolidin-1-yl)-N'-(diphenylmethylidene) carbazate

Downstream raw materials:

N-(N-benzhydrylidene-2-aza-2-propargylglycinyl)-L-phenylalanine tert-butyl ester

(2’S)-1-((diphenylmethylene)amino)-3-(tert-butyl-3’-phenylpropanoate)imidazolidin-2-one

(2’R)-1-((diphenylmethylene)amino)-3-(tert-butyl-3’-phenylpropanoate)imidazolidin-2-one