1-[4-(3-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

Base Information

Chemical Name:1-[4-(3-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone
CAS No.:111626-75-6
Molecular Formula:C₃₀H₃₄FNO₃
Molecular Weight:475.603
Hs Code.:

Synonyms:1-[4-(3-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

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Chemical Property of 1-[4-(3-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

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Technology Process of 1-[4-(3-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

There total 5 articles about 1-[4-(3-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96835-27-7
α-(4-Fluorophenyl)-α-phenyl-4-pyridinemethanol

: 111626-75-6
1-[4-(3-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorous, 57percent aq. HI / acetic acid / 11 h / Heating

2: H₂ / 5percent Pd/C / acetic acid / 16 h / 2534.03 Torr / Ambient temperature

3: K₂CO₃, KI / butan-1-ol / Heating

With phosphorus; hydrogen iodide; hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In acetic acid; butan-1-ol;
DOI:10.1021/jm00114a009

Reference yield:

: 14548-46-0
4-Benzoylpyridine

: 111626-75-6
1-[4-(3-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / tetrahydrofuran; diethyl ether / 1.) RT, 0.5 h, 2.) reflux, 4 h

2: phosphorous, 57percent aq. HI / acetic acid / 11 h / Heating

3: H₂ / 5percent Pd/C / acetic acid / 16 h / 2534.03 Torr / Ambient temperature

4: K₂CO₃, KI / butan-1-ol / Heating

With phosphorus; hydrogen iodide; hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetic acid; butan-1-ol;
DOI:10.1021/jm00114a009

Reference yield:

: 135256-94-9
4-[(4-Fluoro-phenyl)-phenyl-methyl]-pyridine

: 111626-75-6
1-[4-(3-{4-[(4-Fluoro-phenyl)-phenyl-methyl]-piperidin-1-yl}-propoxy)-3-methoxy-phenyl]-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / acetic acid / 16 h / 2534.03 Torr / Ambient temperature

2: K₂CO₃, KI / butan-1-ol / Heating

With hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In acetic acid; butan-1-ol;
DOI:10.1021/jm00114a009