(2R,5S)-benzyl 2-((E)-5,5-diethoxy-4-oxohept-2-enyl)-5-(2-oxobutyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2R,5S)-benzyl 2-((E)-5,5-diethoxy-4-oxohept-2-enyl)-5-(2-oxobutyl)pyrrolidine-1-carboxylate
CAS No.:1260521-98-9
Molecular Formula:C₂₇H₃₉NO₆
Molecular Weight:473.61
Hs Code.:

Synonyms:(2R,5S)-benzyl 2-((E)-5,5-diethoxy-4-oxohept-2-enyl)-5-(2-oxobutyl)pyrrolidine-1-carboxylate

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Chemical Property of (2R,5S)-benzyl 2-((E)-5,5-diethoxy-4-oxohept-2-enyl)-5-(2-oxobutyl)pyrrolidine-1-carboxylate

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Technology Process of (2R,5S)-benzyl 2-((E)-5,5-diethoxy-4-oxohept-2-enyl)-5-(2-oxobutyl)pyrrolidine-1-carboxylate

There total 3 articles about (2R,5S)-benzyl 2-((E)-5,5-diethoxy-4-oxohept-2-enyl)-5-(2-oxobutyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 231285-44-2
(MeO)2P(O)CH₂COC(OEt)2Et

: 1260521-94-5
(2S,5R)-benzyl 2-(2-oxobutyl)-5-(2-oxoethyl)pyrrolidine-1-carboxylate

: 1260521-98-9
(2R,5S)-benzyl 2-((E)-5,5-diethoxy-4-oxohept-2-enyl)-5-(2-oxobutyl)pyrrolidine-1-carboxylate

Guidance literature:: (MeO)2P(O)CH₂COC(OEt)2Et; With potassium hexamethylsilazane; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

(2S,5R)-benzyl 2-(2-oxobutyl)-5-(2-oxoethyl)pyrrolidine-1-carboxylate; In tetrahydrofuran; at 0 - 70 ℃; for 16.17h; chemoselective reaction; Inert atmosphere;
DOI:10.3987/COM-10-12010

Reference yield:

: 1260521-86-5
C₂₃H₃₃NO₅

: 1260521-98-9
(2R,5S)-benzyl 2-((E)-5,5-diethoxy-4-oxohept-2-enyl)-5-(2-oxobutyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; pyridinium p-toluenesulfonate / 16 h / 50 °C

2.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -60 - 20 °C / Inert atmosphere

3.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

3.2: 16.17 h / 0 - 70 °C / Inert atmosphere

With oxalyl dichloride; ethanol; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2.1: Swern oxidation / 3.1: Horner-Wadsworth-Emmons condensation / 3.2: Horner-Wadsworth-Emmons condensation;
DOI:10.3987/COM-10-12010

Reference yield:

: 1260521-90-1
C₁₈H₂₅NO₄

: 1260521-98-9
(2R,5S)-benzyl 2-((E)-5,5-diethoxy-4-oxohept-2-enyl)-5-(2-oxobutyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -60 - 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

2.2: 16.17 h / 0 - 70 °C / Inert atmosphere

With oxalyl dichloride; potassium hexamethylsilazane; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation / 2.1: Horner-Wadsworth-Emmons condensation / 2.2: Horner-Wadsworth-Emmons condensation;
DOI:10.3987/COM-10-12010