3-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2,5-dichloro-4,6-dimethylpyridine 1-oxide

Base Information

• Chemical Name: 3-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2,5-dichloro-4,6-dimethylpyridine 1-oxide
• CAS No.: 1044137-00-9
• Molecular Formula: C₂₉H₂₂Cl₂N₄O₆
• Molecular Weight: 593.423

Synonyms:3-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2,5-dichloro-4,6-dimethylpyridine 1-oxide

Chemical Property of 3-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2,5-dichloro-4,6-dimethylpyridine 1-oxide

Chemical Property:

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Technology Process of 3-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2,5-dichloro-4,6-dimethylpyridine 1-oxide

There total 4 articles about 3-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2,5-dichloro-4,6-dimethylpyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-(3,4-bis(benzyloxy)-5-nitrophenyl)-3-(2,5-dichloro-4,6-dimethylpyridin-3-yl)-1,2,4-oxadiazole (1044136-99-3) → 3-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2,5-dichloro-4,6-dimethylpyridine 1-oxide (1044137-00-9)

Guidance literature:

With urea hydrogen peroxide adduct; trifluoroacetic anhydride; In dichloromethane; at 20 ℃; Inert atmosphere; Cooling;

DOI:10.1021/jm1001524

Reference yield:

3,4-bis(benzyloxy)-5-nitrobenzoic acid (923288-55-5) → 3-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2,5-dichloro-4,6-dimethylpyridine 1-oxide (1044137-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 5 h / 135 °C

2: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 20 °C / Cooling with ice

With urea hydrogen peroxide adduct; 1,1'-carbonyldiimidazole; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2,5-dichloro-N′-hydroxy-4,6-dimethylnicotinamide → 3-(5-(3,4-bis(benzyloxy)-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-2,5-dichloro-4,6-dimethylpyridine 1-oxide (1044137-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 5 h / 135 °C

2: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 20 °C / Cooling with ice

With urea hydrogen peroxide adduct; 1,1'-carbonyldiimidazole; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

5-(3,4-bis(benzyloxy)-5-nitrophenyl)-3-(2,5-dichloro-4,6-dimethylpyridin-3-yl)-1,2,4-oxadiazole

3,4-bis(benzyloxy)-5-nitrobenzoic acid

2,5-dichloro-N'-hydroxy-4,6-dimethylnicotinimidamide

Downstream raw materials:

2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide

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