(S)-2-((1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-3-phenyl propanoic acid

Base Information

• Chemical Name: (S)-2-((1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-3-phenyl propanoic acid
• CAS No.: 1260227-23-3
• Molecular Formula: C₁₇H₁₅BrF₃NO₂
• Molecular Weight: 402.211
• Mol file: 1260227-23-3.mol

Synonyms:(S)-2-((1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-3-phenyl propanoic acid

Chemical Property of (S)-2-((1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-3-phenyl propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-3-phenyl propanoic acid

There total 6 articles about (S)-2-((1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-3-phenyl propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H12BrF3NO2(1-)*K(1+) → (S)-2-((1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-3-phenyl propanoic acid (1260227-23-3)

Guidance literature:

C₁₇H₁₂BrF₃NO₂^(1-)*K⁽¹⁺⁾; With zinc(II) tetrahydroborate; In acetonitrile; at -40 ℃;

With hydrogenchloride; In water; stereoselective reaction;

DOI:10.1016/j.bmcl.2010.10.015

Reference yield:

C17H12BrF3NO2(1-)*K(1+) → (S)-2-((1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-3-phenyl propanoic acid (1260227-23-3) + (S)-2-((1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-3-phenyl propanoic acid

Guidance literature:

With zinc(II) tetrahydroborate; In methanol; 1,2-dimethoxyethane; acetonitrile; at -45 - 40 ℃; for 3h; diastereoselective reaction;

DOI:10.1016/j.bmc.2019.115083

Reference yield:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → (S)-2-((1-(4-bromophenyl)-2,2,2-trifluoroethyl)amino)-3-phenyl propanoic acid (1260227-23-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 18 h / 75 °C / Inert atmosphere

2: zinc(II) tetrahydroborate / methanol; acetonitrile; tetrahydrofuran / 4 h / -40 °C

With zinc(II) tetrahydroborate; potassium carbonate; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1016/j.bmcl.2020.127439

upstream raw materials:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

L-phenylalanine

4'-bromo-2,2,2-trifluoroacetophenone