t-butyl 4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazine-1-carboxylate

Base Information

Chemical Name:t-butyl 4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazine-1-carboxylate
CAS No.:1280197-79-6
Molecular Formula:C₂₆H₂₈F₃N₅O₄
Molecular Weight:531.535
Hs Code.:

Synonyms:t-butyl 4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazine-1-carboxylate

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Chemical Property of t-butyl 4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazine-1-carboxylate

Chemical Property:

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Technology Process of t-butyl 4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazine-1-carboxylate

There total 8 articles about t-butyl 4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₆F₃N₅O₄

: 1280197-79-6
t-butyl 4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazine-1-carboxylate

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm101340q

Reference yield:

: 1268264-34-1
3-bromo-5-nitro-7-trifluoromethylquinoline

: 1280197-79-6
t-butyl 4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 8 h / 110 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water / Reflux

3: ethanol / Inert atmosphere; Reflux

4: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; water; toluene; 1: Buchwald-Hartwig coupling;
DOI:10.1021/jm101340q

Reference yield:

: 1280198-07-3
t-butyl 4-(5-nitro-7-(trifluoromethyl)quinolin-3-yl)piperazine-1-carboxylate

: 1280197-79-6
t-butyl 4-(5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolin-3-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: iron; ammonium chloride / ethanol; water / Reflux

2: ethanol / Inert atmosphere; Reflux

3: sodium tetrahydroborate / ethanol / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; iron; ammonium chloride; In ethanol; water;
DOI:10.1021/jm101340q