1-(4-((tetrahydro-2H-pyran-4-yl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pent-1-en-3-one

Base Information

• Chemical Name: 1-(4-((tetrahydro-2H-pyran-4-yl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pent-1-en-3-one
• CAS No.: 1459258-37-7
• Molecular Formula: C₃₅H₃₄N₄O₂
• Molecular Weight: 542.681
• Mol file: 1459258-37-7.mol

Synonyms:1-(4-((tetrahydro-2H-pyran-4-yl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pent-1-en-3-one

Chemical Property of 1-(4-((tetrahydro-2H-pyran-4-yl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pent-1-en-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-((tetrahydro-2H-pyran-4-yl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pent-1-en-3-one

There total 1 articles about 1-(4-((tetrahydro-2H-pyran-4-yl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pent-1-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-penten-3-one (1629-58-9) + 3-iodo-N-(tetrahydro-2H-pyran-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine → 1-(4-((tetrahydro-2H-pyran-4-yl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pent-1-en-3-one (1459258-37-7)

Guidance literature:

With dichlorobis(tri-O-tolylphosphine)palladium; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Sealed tube;

DOI:10.1016/j.bmcl.2018.10.017

Reference yield: 98.0%

1-(4-((tetrahydro-2H-pyran-4-yl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pent-1-en-3-one (1459258-37-7) → 3-(5-ethyl-1H-pyrazol-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine (1459258-29-7)

Guidance literature:

1-(4-((tetrahydro-2H-pyran-4-yl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pent-1-en-3-one; With hydrazine hydrate; In N,N-dimethyl-formamide; at 180 ℃; for 0.166667h; Microwave irradiation;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃;

Reference yield:

1-(4-((tetrahydro-2H-pyran-4-yl)amino)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)pent-1-en-3-one (1459258-37-7) → C36H36N6O

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrazine hydrate / N,N-dimethyl-formamide / 0.17 h / 180 °C / Microwave irradiation

1.2: 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

With caesium carbonate; hydrazine hydrate; In N,N-dimethyl-formamide;

upstream raw materials:

4-penten-3-one

Downstream raw materials:

3-(5-ethyl-1H-pyrazol-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine