5-{[2-(4-aminophenyl)ethyl]oxy}-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Base Information

• Chemical Name: 5-{[2-(4-aminophenyl)ethyl]oxy}-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide
• CAS No.: 869295-73-8
• Molecular Formula: C₂₅H₂₃FN₄O₄
• Molecular Weight: 462.48

Synonyms:5-{[2-(4-aminophenyl)ethyl]oxy}-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Chemical Property of 5-{[2-(4-aminophenyl)ethyl]oxy}-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Chemical Property:

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Technology Process of 5-{[2-(4-aminophenyl)ethyl]oxy}-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

There total 1 articles about 5-{[2-(4-aminophenyl)ethyl]oxy}-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-{[2-(4-aminophenyl)ethyl]oxy}-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide (869295-73-8)

Guidance literature:

Reference yield: 100.0%

5-{[2-(4-aminophenyl)ethyl]oxy}-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide (869295-73-8) + (tert-butoxycarbonyl)-((4-(dimethyliminio)pyridin-1(4H)-yl)sulfonyl)amide (352275-00-4,872496-91-8) → 1,1-dimethylethyl [({4-[2-({6-fluoro-2-[({[3-(methyloxy)phenyl]methyl}amino)carbonyl]-4-oxo-3,4-dihydroquinazolin-5-yl}oxy)ethyl]phenyl}amino)sulfonyl]carbamate

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 15h;

Reference yield: 88.0%

5-{[2-(4-aminophenyl)ethyl]oxy}-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide (869295-73-8) + Glycine ethyl ester isocyanate (2949-22-6) → 5-({2-[4-(2,5-dioxoimidazolidin-1-yl)phenyl]ethyl}oxy)-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide

Guidance literature:

5-{[2-(4-aminophenyl)ethyl]oxy}-6-fluoro-N-{[3-(methyloxy)phenyl]methyl}-4-oxo-3,4-dihydroquinazoline-2-carboxamide; Glycine ethyl ester isocyanate; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogenchloride; ethanol; water; In tetrahydrofuran; for 8h; Heating / reflux;

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