(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

Base Information

Chemical Name:(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine
CAS No.:1429199-85-8
Molecular Formula:C₁₄H₂₀N₄O
Molecular Weight:260.339
Hs Code.:

Synonyms:(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

Suppliers and Price of (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

There total 1 articles about (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 1429199-85-8
(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzene / 5 h / Reflux

2.1: triethylamine / 2-ethoxy-ethanol / 12 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 20 °C

4.2: 48 h / 20 °C

5.1: hydrogen; 20% palladium hydroxide-activated charcoal / tetrahydrofuran / 16 h / 50 °C / 1551.49 Torr

With lithium aluminium tetrahydride; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; benzene;

Reference yield: 46.0%

: 1429199-85-8
(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine

: 98-59-9
p-toluenesulfonyl chloride

: 76-05-1
trifluoroacetic acid

: (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[(4-methylphenyl)sulfonyl]-octahydropyrrolo[1,2-a]pyrazine trifluoroacetate

Guidance literature:: (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine; p-toluenesulfonyl chloride; With pyridine; In dichloromethane; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;