3-chloro-4-methylphenyl(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)carbamic acid benzyl ester

Base Information

Chemical Name:3-chloro-4-methylphenyl(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)carbamic acid benzyl ester
CAS No.:1221446-12-3
Molecular Formula:C₃₂H₃₈ClN₃O₄S
Molecular Weight:596.19
Hs Code.:

Synonyms:3-chloro-4-methylphenyl(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)carbamic acid benzyl ester

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Chemical Property of 3-chloro-4-methylphenyl(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)carbamic acid benzyl ester

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Technology Process of 3-chloro-4-methylphenyl(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)carbamic acid benzyl ester

There total 7 articles about 3-chloro-4-methylphenyl(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1221446-26-9
3-chloro-4-methylphenyl(3-chloropropyl)carbamic acid benzyl ester

: 1221446-24-7
N-(3-exo-8-azabicyclo[3.2.1]oct-3-yl)-4-toluenesulfonamide

: 1221446-12-3
3-chloro-4-methylphenyl(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)carbamic acid benzyl ester

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; for 6h; Reflux;

Reference yield:

: 76272-34-9
8-benzyl-8-azabicyclo[3.2.1] octan-3-one oxime

: 1221446-12-3
3-chloro-4-methylphenyl(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium; pentan-1-ol / 2 h / Reflux

2: triethylamine / dichloromethane / 6 h / 20 °C

3: ammonium formate / palladium 10% on activated carbon / methanol / 12 h / Reflux

4: potassium carbonate / potassium iodide / acetonitrile / 6 h / Reflux

With pentan-1-ol; ammonium formate; sodium; potassium carbonate; triethylamine; palladium 10% on activated carbon; potassium iodide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 542-05-2
acetonedicarboxylic acid

: 1221446-12-3
3-chloro-4-methylphenyl(3-(3-exo-(4-tolylsulfonamido)-8-azabicyclo[3.2.1]oct-8-yl)propyl)carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; water / 1 h / Reflux

1.2: 6 h / 0 - 50 °C

1.3: pH 12

2.1: hydroxylamine hydrochloride; pyridine / ethanol / 18 h / Reflux

3.1: sodium; pentan-1-ol / 2 h / Reflux

4.1: triethylamine / dichloromethane / 6 h / 20 °C

5.1: ammonium formate / palladium 10% on activated carbon / methanol / 12 h / Reflux

6.1: potassium carbonate / potassium iodide / acetonitrile / 6 h / Reflux

With pyridine; hydrogenchloride; pentan-1-ol; hydroxylamine hydrochloride; water; ammonium formate; sodium; potassium carbonate; triethylamine; palladium 10% on activated carbon; potassium iodide; In methanol; ethanol; dichloromethane; acetonitrile;