tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-hydroxyethyl)carbamate

Base Information

Chemical Name:tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-hydroxyethyl)carbamate
CAS No.:1300035-77-1
Molecular Formula:C₂₅H₃₂BrNO₅
Molecular Weight:506.437
Hs Code.:

Synonyms:tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-hydroxyethyl)carbamate

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Chemical Property of tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-hydroxyethyl)carbamate

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Technology Process of tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-hydroxyethyl)carbamate

There total 2 articles about tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-hydroxyethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1300035-75-9
tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate

: 1300035-77-1
tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-hydroxyethyl)carbamate

Guidance literature:: tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With water; In tetrahydrofuran;
DOI:10.1021/ol200725m

Reference yield:

: 1300035-27-1
tert-butyl (S)-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)carbamate

: 1300035-77-1
tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-hydroxyethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; potassium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol200725m

Reference yield: 80.0%

: 1300035-77-1
tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-hydroxyethyl)carbamate

: 1300035-31-7
tert-butyl (S)-N-(1-(2-bromo-5-methoxyphenyl)-3-(3-methoxyphenyl)but-3-en-2-yl)-N-(2-oxoethyl)carbamate

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃; for 1.75h; Inert atmosphere;
DOI:10.1021/ol200725m