4-(azetidine-1-carbonyl)-1-methyl-N-(8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:4-(azetidine-1-carbonyl)-1-methyl-N-(8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxamide
CAS No.:1380329-84-9
Molecular Formula:C₂₂H₂₁N₇O₂
Molecular Weight:415.454
Hs Code.:

Synonyms:4-(azetidine-1-carbonyl)-1-methyl-N-(8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxamide

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Chemical Property of 4-(azetidine-1-carbonyl)-1-methyl-N-(8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxamide

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Technology Process of 4-(azetidine-1-carbonyl)-1-methyl-N-(8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxamide

There total 7 articles about 4-(azetidine-1-carbonyl)-1-methyl-N-(8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.3%

: 1278407-69-4
4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1380331-24-7
8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-amine

: 1380329-84-9
4-(azetidine-1-carbonyl)-1-methyl-N-(8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: 8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-amine; With trimethylaluminum; In 1,4-dioxane; toluene; at 25 ℃; for 1h; Inert atmosphere;

4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester; In 1,4-dioxane; toluene; at 100 ℃; for 72h;

Reference yield:

: 1380331-21-4
methyl 8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridine-7-carboxylate

: 1380329-84-9
4-(azetidine-1-carbonyl)-1-methyl-N-(8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water / tetrahydrofuran / 72 h / 25 °C

1.2: pH 0

2.1: triethylamine; diphenyl phosphoryl azide / ethyl acetate; n-heptane; tert-butyl alcohol; methanol / 24 h / 25 °C / Reflux

3.1: trimethylaluminum / toluene; 1,4-dioxane / 1 h / 25 °C / Inert atmosphere

3.2: 72 h / 100 °C

With diphenyl phosphoryl azide; water; trimethylaluminum; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; n-heptane; ethyl acetate; toluene; tert-butyl alcohol;

Reference yield:

: 1174886-97-5
5-(ethoxycarbonyl)-1-methyl-1H-pyrazole-4-carboxylic acid

: 1380329-84-9
4-(azetidine-1-carbonyl)-1-methyl-N-(8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 3 h / 20 °C / Cooling

2.1: trimethylaluminum / toluene; 1,4-dioxane / 1 h / 25 °C / Inert atmosphere

2.2: 72 h / 100 °C

With trimethylaluminum; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethyl acetate; toluene;