3-Quinolinol,1,2,3,4-tetrahydro-

Base Information

• Chemical Name: 3-Quinolinol,1,2,3,4-tetrahydro-
• CAS No.: 3418-45-9
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• Hs Code.: 2933499090
• Mol file: 3418-45-9.mol

Synonyms:3-QUINOLINOL;3-Quinolinol, 1,2,3,4-tetrahydro-

Chemical Property of 3-Quinolinol,1,2,3,4-tetrahydro-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 87 °C
• Refractive Index: 1.586
• Boiling Point: 318.686°C at 760 mmHg
• PKA: 4.28(at 20℃)
• Flash Point: 173.868°C
• PSA: 32.26000
• Density: 1.154g/cm³
• LogP: 1.15350
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

1,2,3,4-Tetrahydroquinolin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Quinolinol,1,2,3,4-tetrahydro-

There total 7 articles about 3-Quinolinol,1,2,3,4-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

quinoline (91-22-5) → 1,2,3,4-tetrahydroquinolin-3-ol (3418-45-9) + 1,2,3,4-tetrahydroquinolin-2-ol

Guidance literature:

quinoline; With borane-THF; boron trichloride; In hexane; at 0 - 65 ℃; for 4h; Inert atmosphere;

With sodium perborate; water; at 20 ℃; for 2h; Reagent/catalyst; Inert atmosphere;

DOI:10.1002/chem.201701944

Reference yield: 48.0%

3-hydroxyquinoline (580-18-7) → 1,2,3,4-tetrahydroquinolin-3-ol (3418-45-9)

Guidance literature:

With ethanol; sodium; at 80 ℃; for 2h;

Reference yield: 45.0%

quinoline (91-22-5) → 1,2,3,4-tetrahydroquinolin-3-ol (3418-45-9)

Guidance literature:

quinoline; With monochloroborane dimethyl sulfide complex; In tetrahydrofuran; at 0 - 65 ℃; for 48h; Inert atmosphere;

With sodium perborate; water; at 20 ℃; for 2h; Reagent/catalyst; Inert atmosphere;

DOI:10.1002/chem.201701944

upstream raw materials:

3-hydroxyquinoline

sulfuric acid

water

quinoline

Refernces

• 1、 Altiti, Ahmad S.,Cheng, Kai Fan,He, Mingzhu,Al-Abed, Yousef. "β-Hydroxy-tetrahydroquinolines from Quinolines Using Chloroborane: Synthesis of the Peptidomimetic FISLE-412". supporting information. p. 10738 - 10743. Retrieved 2017/08/22.