N-im-tosyl-L-histidyl>amino>-2,2-difluoro-3(S)-amino-6-methylheptanoyl>-L-isoleucyl>-2-pyridylmethylamine

Base Information

Chemical Name:N-im-tosyl-L-histidyl>amino>-2,2-difluoro-3(S)-amino-6-methylheptanoyl>-L-isoleucyl>-2-pyridylmethylamine
CAS No.:109553-32-4
Molecular Formula:C₄₇H₆₃F₂N₉O₈S
Molecular Weight:952.136
Hs Code.:

N-<N-<4(S)-<<N''-(trt-butyloxycarbonyl)-L-phenylalanyl-N<sup>im</sup>-tosyl-L-histidyl>amino>-2,2-difluoro-3(S)-amino-6-methylheptanoyl>-L-isoleucyl>-2-pyridylmethylamine

Synonyms:N-im-tosyl-L-histidyl>amino>-2,2-difluoro-3(S)-amino-6-methylheptanoyl>-L-isoleucyl>-2-pyridylmethylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-im-tosyl-L-histidyl>amino>-2,2-difluoro-3(S)-amino-6-methylheptanoyl>-L-isoleucyl>-2-pyridylmethylamine

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Technology Process of N-im-tosyl-L-histidyl>amino>-2,2-difluoro-3(S)-amino-6-methylheptanoyl>-L-isoleucyl>-2-pyridylmethylamine

There total 21 articles about N-im-tosyl-L-histidyl>amino>-2,2-difluoro-3(S)-amino-6-methylheptanoyl>-L-isoleucyl>-2-pyridylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 109553-31-3
N-im-tosyl-L-histidyl>amino>-2,2-difluoro-3(S)-<(4-methoxyphenyl)amino>-6-methylheptanoyl>-L-isoleucyl>-2-pyridylmethylamine

: 109553-32-4
N-im-tosyl-L-histidyl>amino>-2,2-difluoro-3(S)-amino-6-methylheptanoyl>-L-isoleucyl>-2-pyridylmethylamine

Guidance literature:: With ammonium cerium(IV) nitrate; In acetonitrile; for 1h; Ambient temperature;
DOI:10.1021/jm00393a026

Reference yield:

: 109553-31-3
C₅₄H₆₉F₂N₉O₉S

: 109553-32-4
C₄₇H₆₃F₂N₉O₈S

Guidance literature:: With ammonium cerium(IV) nitrate; In acetonitrile; for 1h; Ambient temperature;
DOI:10.1021/jm00393a026

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 109553-32-4
N-im-tosyl-L-histidyl>amino>-2,2-difluoro-3(S)-amino-6-methylheptanoyl>-L-isoleucyl>-2-pyridylmethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylethylamine, diethylphosphoryl cyanide / CH₂Cl₂ / 20 h / Ambient temperature

2: 48 percent / aq. ceric ammonium nitrate / acetonitrile / 1 h / Ambient temperature

With diethylphosphoryl cyanide; ammonium cerium(IV) nitrate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm00393a026