Technology Process of 3-[4-(2,8-dimethylthieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid
There total 1 articles about 3-[4-(2,8-dimethylthieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl]-2,2-dimethylpropanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / dimethyl sulfoxide / 70 °C / 1551.49 Torr
2: sodium hydroxide; water / methanol / 0.75 h / 65 °C
3: acetic acid; bromine / 1 h / 20 °C
4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C
5: pyridine / tetrahydrofuran / 2 h / 20 °C
6: potassium carbonate / dimethyl sulfoxide / 4 h / 140 °C
7: N,N-dimethyl-aniline; trichlorophosphate / 2.25 h / 60 - 100 °C
8: potassium carbonate / acetonitrile / 3 h / 82 °C
9: sodium hydroxide; water / isopropyl alcohol / 1.5 h / 85 °C
With
pyridine; oxalyl dichloride; 1,3-bis-(diphenylphosphino)propane; water; bromine; palladium diacetate; potassium carbonate; acetic acid; N,N-dimethyl-aniline; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol; acetonitrile;
- Guidance literature:
-
In
ethanol;
at 50 ℃;
for 0.5h;
