1-(5-Chloropyrazin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Base Information

Chemical Name:1-(5-Chloropyrazin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol
CAS No.:1416805-74-7
Molecular Formula:C₁₄H₉ClF₄N₆O
Molecular Weight:388.712
Hs Code.:

Synonyms:1-(5-Chloropyrazin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

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Chemical Property of 1-(5-Chloropyrazin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

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Technology Process of 1-(5-Chloropyrazin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

There total 3 articles about 1-(5-Chloropyrazin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.2%

: 288-94-8
1H-tetrazole

: 1416806-22-8
C₁₃H₇ClF₄N₂O

: 1416805-74-7
1-(5-Chloropyrazin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 70 ℃; Inert atmosphere;

Reference yield:

: 1416806-20-6
ethyl 2-(5-chloropyrazin-2-yl)-2,2-difluoroacetate

: 1416805-74-7
1-(5-Chloropyrazin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; diethyl ether / -78 °C

1.2: 0.08 h / -78 °C

2.1: diethyl ether / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 70 °C / Inert atmosphere

With n-butyllithium; potassium carbonate; In diethyl ether; hexane; N,N-dimethyl-formamide;

Reference yield:

: 1416806-21-7
C₁₂H₅ClF₄N₂O

: 1416805-74-7
1-(5-Chloropyrazin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 - 70 °C / Inert atmosphere

With potassium carbonate; In diethyl ether; N,N-dimethyl-formamide;