N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-[4-(1-piperidinyl)-butyl]pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

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Chemical Name:N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-[4-(1-piperidinyl)-butyl]pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide
CAS No.:1192682-81-7
Molecular Formula:C₂₈H₃₈N₄O₃
Molecular Weight:478.635
Hs Code.:

Synonyms:N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-[4-(1-piperidinyl)-butyl]pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

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Chemical Property of N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-[4-(1-piperidinyl)-butyl]pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

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Technology Process of N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-[4-(1-piperidinyl)-butyl]pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

There total 9 articles about N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-[4-(1-piperidinyl)-butyl]pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192685-74-7
N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-[(1E/Z)-4-(1-piperidinyl)-1-buten-1-yl]pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

: 1192682-81-7
N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-[4-(1-piperidinyl)-butyl]pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 12h; under 760.051 Torr;

Reference yield:

: 72652-33-6
4-iodo-2-(trichloroacetyl)pyrrole

: 1192682-81-7
N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-[4-(1-piperidinyl)-butyl]pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: ammonium acetate; acetic acid / 40 h / Heating; Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

3.2: 0 - 65 °C

4.1: triethylamine; tris-(o-tolyl)phosphine / palladium diacetate / N,N-dimethyl-formamide / 3 h / 100 °C

5.1: dmap; triethylamine / chloroform / 0 - 20 °C

6.1: potassium carbonate / acetonitrile / 8 h / 80 °C

7.1: hydrogen / palladium on activated charcoal / ethanol / 12 h / 20 °C / 760.05 Torr

With dmap; ammonium acetate; hydrogen; sodium hydride; potassium carbonate; acetic acid; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; palladium diacetate; In ethanol; chloroform; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1192685-72-5
(3E/Z)-4-{2-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-[3-(methyloxy)-phenyl]-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-7-yl}-3-buten-1-yl methanesulfonate

: 1192682-81-7
N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-[4-(1-piperidinyl)-butyl]pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 8 h / 80 °C

2: hydrogen / palladium on activated charcoal / ethanol / 12 h / 20 °C / 760.05 Torr

With hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; acetonitrile;