(5R,9R)-tert-butyl 9-dodecanamido-3,12-dioxo-1-phenyl-2-oxa-7-thia-4,11-diazatricosane-5-carboxylate

Base Information

Chemical Name:(5R,9R)-tert-butyl 9-dodecanamido-3,12-dioxo-1-phenyl-2-oxa-7-thia-4,11-diazatricosane-5-carboxylate
CAS No.:1337527-06-6
Molecular Formula:C₄₂H₇₃N₃O₆S
Molecular Weight:748.124
Hs Code.:

Synonyms:(5R,9R)-tert-butyl 9-dodecanamido-3,12-dioxo-1-phenyl-2-oxa-7-thia-4,11-diazatricosane-5-carboxylate

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Chemical Property of (5R,9R)-tert-butyl 9-dodecanamido-3,12-dioxo-1-phenyl-2-oxa-7-thia-4,11-diazatricosane-5-carboxylate

Chemical Property:

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Technology Process of (5R,9R)-tert-butyl 9-dodecanamido-3,12-dioxo-1-phenyl-2-oxa-7-thia-4,11-diazatricosane-5-carboxylate

There total 8 articles about (5R,9R)-tert-butyl 9-dodecanamido-3,12-dioxo-1-phenyl-2-oxa-7-thia-4,11-diazatricosane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112-16-3
n-dodecanoyl chloride

: 1337527-05-5
(R)-tert-butyl 2-(benzyloxycarbonylamino)-3-((R)-2,3-diaminopropylthio)propanoate

: 1337527-06-6
(5R,9R)-tert-butyl 9-dodecanamido-3,12-dioxo-1-phenyl-2-oxa-7-thia-4,11-diazatricosane-5-carboxylate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 2.08333h;

Reference yield:

: 105729-42-8
N,N'-bis(carbobenzyloxy)-L-cystine di-tert-butyl ester

: 1337527-06-6
(5R,9R)-tert-butyl 9-dodecanamido-3,12-dioxo-1-phenyl-2-oxa-7-thia-4,11-diazatricosane-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; 1,4-dithio-erythritol / dichloromethane / 1.5 h / 20 °C

2.1: sodium hydroxide / tert-butyl alcohol / 20 °C

2.2: 15 h / 20 °C

3.1: dmap; pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 16 h / 20 - 50 °C

5.1: hydrogen / palladium(II) hydroxide / ethanol / 16 h / 20 °C / 760.05 Torr / Inert atmosphere

6.1: pyridine / dichloromethane / 2.08 h / 0 - 20 °C

With pyridine; dmap; sodium azide; 1,4-dithio-erythritol; hydrogen; triethylamine; sodium hydroxide; palladium(II) hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 656238-22-1
(R)-tert-butyl 2-(benzyloxycarbonylamino)-3-mercaptopropanoate

: 1337527-06-6
(5R,9R)-tert-butyl 9-dodecanamido-3,12-dioxo-1-phenyl-2-oxa-7-thia-4,11-diazatricosane-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / tert-butyl alcohol / 20 °C

1.2: 15 h / 20 °C

2.1: dmap; pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 16 h / 20 - 50 °C

4.1: hydrogen / palladium(II) hydroxide / ethanol / 16 h / 20 °C / 760.05 Torr / Inert atmosphere

5.1: pyridine / dichloromethane / 2.08 h / 0 - 20 °C

With pyridine; dmap; sodium azide; hydrogen; sodium hydroxide; palladium(II) hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;