(S)-2-[4-(2,6-difluoro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-[4-(2,6-difluoro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester
CAS No.:1191998-72-7
Molecular Formula:C₁₈H₂₁F₂NO₅
Molecular Weight:369.365
Hs Code.:

Synonyms:(S)-2-[4-(2,6-difluoro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester

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Chemical Property of (S)-2-[4-(2,6-difluoro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester

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Technology Process of (S)-2-[4-(2,6-difluoro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester

There total 1 articles about (S)-2-[4-(2,6-difluoro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1191998-71-6
(E)-4-bromo-3-(2,6-difluoro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 1191998-72-7
(S)-2-[4-(2,6-difluoro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester

Guidance literature:: (E)-4-bromo-3-(2,6-difluoro-3-methoxy-phenoxy)-but-2-enoic acid ethyl ester; methyl (L)-leucinate hydrochloride; With triethylamine; In acetonitrile; for 12h; Reflux;

In tetrahydrofuran; at 160 ℃; for 1.5h;

Reference yield: 87.0%

: 1191998-72-7
(S)-2-[4-(2,6-difluoro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester

: 1191998-73-8
(S)-2-[4-(2,6-difluoro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid

Guidance literature:: (S)-2-[4-(2,6-difluoro-3-methoxy-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid methyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 5 ℃; for 3h;

With hydrogenchloride; In water; pH=< 2;