(S)-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride

Base Information

Chemical Name:(S)-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride
CAS No.:1335122-59-2
Molecular Formula:C₂₄H₃₃IN₄O₃*ClH
Molecular Weight:588.916
Hs Code.:

Synonyms:(S)-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride

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Chemical Property of (S)-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride

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Technology Process of (S)-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride

There total 8 articles about (S)-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1335122-64-9
C₃₄H₄₉IN₄O₇

: 1335122-59-2
(S)-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 8h;
DOI:10.1016/j.bmc.2011.07.008

Reference yield:

: 1335122-78-5
C₃₄H₅₁N₅O₇

: 1335122-59-2
(S)-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water

2: hydrogenchloride / ethyl acetate / 8 h / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; potassium iodide; sodium nitrite; In water; ethyl acetate;
DOI:10.1016/j.bmc.2011.07.008

Reference yield:

: 1186120-57-9
tert-butyl (1S,2R)-3-bromo-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

: 1335122-59-2
(S)-N-((2S,3S)-2-amino-3-hydroxy-3-(4-iodophenyl)propyl)-2-((R)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

4: iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate

5: toluene-4-sulfonic acid; potassium iodide; sodium nitrite / water

6: hydrogenchloride / ethyl acetate / 8 h / 20 °C

With hydrogenchloride; sodium azide; iron(III) chloride hexahydrate; pyrographite; benzotriazol-1-ol; toluene-4-sulfonic acid; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; potassium iodide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.008