N-(4-chlorophenyl)-2,2-dimethylmalonic acid monoamide

Base Information

Chemical Name:N-(4-chlorophenyl)-2,2-dimethylmalonic acid monoamide
CAS No.:184041-08-5
Molecular Formula:C₁₁H₁₂ClNO₃
Molecular Weight:241.674
Hs Code.:

Synonyms:N-(4-chlorophenyl)-2,2-dimethylmalonic acid monoamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chlorophenyl)-2,2-dimethylmalonic acid monoamide

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Technology Process of N-(4-chlorophenyl)-2,2-dimethylmalonic acid monoamide

There total 6 articles about N-(4-chlorophenyl)-2,2-dimethylmalonic acid monoamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropionamide

: 184041-08-5
N-(4-chlorophenyl)-2,2-dimethylmalonic acid monoamide

Guidance literature:: N-(4-chlorophenyl)-3-hydroxy-2,2-dimethylpropionamide; With periodic acid; In acetonitrile; at 0 ℃; for 0.25h;

With pyridinium chlorochromate; In acetonitrile;
DOI:10.1021/jacs.7b07488

Reference yield:

: 106-47-8
4-chloro-aniline

: 184041-08-5
N-(4-chlorophenyl)-2,2-dimethylmalonic acid monoamide

Guidance literature:: Multi-step reaction with 2 steps

1: benzene

2: alcoholic NaOH-solution

With sodium hydroxide; benzene;

Reference yield:

: 595-46-0
2,2-dimethylmalonic acid

: 184041-08-5
N-(4-chlorophenyl)-2,2-dimethylmalonic acid monoamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / tetrahydrofuran / 2 h / Heating

2: tetrahydrofuran; diethyl ether / 0.5 h

With thionyl chloride; In tetrahydrofuran; diethyl ether; 1: Chlorination / 2: Acylation;
DOI:10.1021/jm9811209