methyl (2R,3R,4S,1'R)-3-amino-4-O-benzyl-5,6-O-isopropylidene-2-methyl-3-N-(1'-phenylethyl)hexanoate

Base Information

Chemical Name:methyl (2R,3R,4S,1'R)-3-amino-4-O-benzyl-5,6-O-isopropylidene-2-methyl-3-N-(1'-phenylethyl)hexanoate
CAS No.:911830-73-4
Molecular Formula:C₂₆H₃₅NO₅
Molecular Weight:441.568
Hs Code.:

Synonyms:methyl (2R,3R,4S,1'R)-3-amino-4-O-benzyl-5,6-O-isopropylidene-2-methyl-3-N-(1'-phenylethyl)hexanoate

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Chemical Property of methyl (2R,3R,4S,1'R)-3-amino-4-O-benzyl-5,6-O-isopropylidene-2-methyl-3-N-(1'-phenylethyl)hexanoate

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Technology Process of methyl (2R,3R,4S,1'R)-3-amino-4-O-benzyl-5,6-O-isopropylidene-2-methyl-3-N-(1'-phenylethyl)hexanoate

There total 4 articles about methyl (2R,3R,4S,1'R)-3-amino-4-O-benzyl-5,6-O-isopropylidene-2-methyl-3-N-(1'-phenylethyl)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 911830-72-3
(2R,3R,4S,1'R)-3-amino-4-O-benzyl-5,6-O-isopropylidene-2-methyl-3-N-(1'-phenylethyl)hexanoic acid

: 911830-73-4
methyl (2R,3R,4S,1'R)-3-amino-4-O-benzyl-5,6-O-isopropylidene-2-methyl-3-N-(1'-phenylethyl)hexanoate

Guidance literature:: In diethyl ether; at 20 ℃; for 0.333333h;
DOI:10.1055/s-2006-942426

Reference yield:

: (2S,3S,1'R)-4-amino-3-O-benzyl-1,2-O-isopropylidene-5-methyl-N-(1'-phenylethyl)-6-heptene-1,2,3-triol

: 911830-73-4
methyl (2R,3R,4S,1'R)-3-amino-4-O-benzyl-5,6-O-isopropylidene-2-methyl-3-N-(1'-phenylethyl)hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / K₂CO₃; K₃[Fe(CN)6]; hydroquinidine 1,4-phthalazinediyl diether / K₂OsO₂(OH)4 / 2-methyl-propan-2-ol; H₂O / 8 h / 20 °C

2: 99 percent / NaIO₄ / methanol; tetrahydrofuran; H₂O / 3 h / 0 °C

3: 90 percent / aq. NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; various solvent(s) / 2.5 h / 20 °C

4: 86 percent / diethyl ether / 0.33 h / 20 °C

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; (DHQD)2PHAL; potassium carbonate; potassium hexacyanoferrate(III); potassium dioxotetrahydroxoosmate(VI); In tetrahydrofuran; methanol; diethyl ether; water; tert-butyl alcohol;
DOI:10.1055/s-2006-942426

Reference yield:

: 911830-71-2
C₂₅H₃₃NO₄

: 911830-73-4
methyl (2R,3R,4S,1'R)-3-amino-4-O-benzyl-5,6-O-isopropylidene-2-methyl-3-N-(1'-phenylethyl)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / aq. NaClO₂; NaH₂PO₄ / 2-methyl-propan-2-ol; various solvent(s) / 2.5 h / 20 °C

2: 86 percent / diethyl ether / 0.33 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; In diethyl ether; tert-butyl alcohol;
DOI:10.1055/s-2006-942426