Technology Process of methyl 2-(5,5-dimethyl-1-cyclopenten-1-yl)-2',6-difluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate
There total 10 articles about methyl 2-(5,5-dimethyl-1-cyclopenten-1-yl)-2',6-difluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate;
palladium diacetate;
In
N,N-dimethyl-formamide;
at 75 ℃;
for 21h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 18 h / 75 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3.1: dmap; triethylamine / dichloromethane / 0.33 h
3.2: 20 °C
4.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere
With
dmap; potassium phosphate; triethylamine; trifluoroacetic acid;
2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate;
In
dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / -78 °C
1.2: 18 h / -78 - 20 °C
2.1: potassium phenolate / bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / toluene / 2 h / 50 °C / Inert atmosphere
3.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 18 h / 75 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
5.1: dmap; triethylamine / dichloromethane / 0.33 h
5.2: 20 °C
6.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / N,N-dimethyl-formamide / 21 h / 75 °C / Inert atmosphere
With
dmap; potassium phosphate; potassium phenolate; triethylamine; trifluoroacetic acid; lithium diisopropyl amide;
bis-triphenylphosphine-palladium(II) chloride; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; n-heptane; dichloromethane; water; N,N-dimethyl-formamide; toluene;