[(3R,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone

Base Information

Chemical Name:[(3R,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone
CAS No.:1435480-81-1
Molecular Formula:C₂₃H₂₃N₇O₂
Molecular Weight:429.481
Hs Code.:

Synonyms:[(3R,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone

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Chemical Property of [(3R,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone

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Technology Process of [(3R,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone

There total 8 articles about [(3R,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192159-68-4
2-(2Η-1,2,3-triazol-2-yl)benzoyl chloride

: 1435479-93-8
(3R,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholine

: 1435480-81-1
[(3R,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 96h;

Reference yield:

: 1435478-21-9
(R)-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-3-one

: 1435480-81-1
[(3R,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; triethylamine / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

2: tetrahydrofuran; diethyl ether / 3 h / -78 °C

3: trifluoroacetic acid / 1 h / 0 °C

4: sodium tetrahydroborate / methanol / 1 h / 0 °C

5: triethylamine / acetonitrile / 96 h / 20 °C

With dmap; sodium tetrahydroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; acetonitrile;

Reference yield:

: 1435478-12-8
(R)-2-amino-3-(3-iodo-phenyl)-propan-1-ol

: 1435480-81-1
[(3R,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere

3: potassium carbonate; copper(l) chloride; L-proline / N,N-dimethyl-formamide / 190 h / 110 °C / Inert atmosphere

4: dmap; triethylamine / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

5: tetrahydrofuran; diethyl ether / 3 h / -78 °C

6: trifluoroacetic acid / 1 h / 0 °C

7: sodium tetrahydroborate / methanol / 1 h / 0 °C

8: triethylamine / acetonitrile / 96 h / 20 °C

With dmap; sodium tetrahydroborate; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; L-proline; copper(l) chloride; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; acetonitrile; mineral oil;