tert-butyl 3-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}benzoate

Base Information

Chemical Name:tert-butyl 3-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}benzoate
CAS No.:1375702-40-1
Molecular Formula:C₂₇H₂₈ClN₅O₂
Molecular Weight:490.005
Hs Code.:

Synonyms:tert-butyl 3-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}benzoate

Suppliers and Price of tert-butyl 3-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 3-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}benzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 3-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}benzoate

There total 4 articles about tert-butyl 3-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 337920-73-7
5-chloro-2-(6-chloropyridin-3-yl)-1H-benzimidazole

: 756751-79-8
tert-butyl 3-(piperazin-1-yl)benzoate

: 1375702-40-1
tert-butyl 3-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 100 ℃; for 16h;

Reference yield:

: 23100-12-1
6-chloronicotinylaldehyde

: 1375702-40-1
tert-butyl 3-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Oxone / N,N-dimethyl-formamide; water / 2 h / 20 °C

1.2: pH 7

2.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 16 h / 100 °C

With Oxone; N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 92146-82-2
tert-butyl 3-aminobenzoate

: 1375702-40-1
tert-butyl 3-{4-[5-(5-chloro-1H-benzimidazol-2-yl)pyridin-2-yl]piperazin-1-yl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / acetone / 16 h / 100 °C

2: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 16 h / 100 °C

With 2,6-dimethylpyridine; N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; acetone;