Technology Process of (6S,7R,E)-7-((4-methoxybenzyl)oxy)-6-(methoxymethoxy)dodec-2-en-1-ol
There total 10 articles about (6S,7R,E)-7-((4-methoxybenzyl)oxy)-6-(methoxymethoxy)dodec-2-en-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
dichloromethane; toluene;
at 20 ℃;
Cooling;
DOI:10.1039/c4ob00323c
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol
2.1: dmap; triethylamine / dichloromethane / 0 - 20 °C
3.1: toluene-4-sulfonic acid / methanol / 0 - 20 °C
4.1: potassium carbonate / methanol / 2 h / 0 °C
5.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C
5.2: 0 - 20 °C
6.1: copper(I) bromide / tetrahydrofuran; diethyl ether / 0 °C
7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 0 - 20 °C
8.1: ozone / dichloromethane / -78 °C / Inert atmosphere
9.1: benzene / 2 h / 20 °C
10.1: diisobutylaluminium hydride / dichloromethane; toluene / 20 °C / Cooling
With
dmap; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; triethylamine; N-ethyl-N,N-diisopropylamine; copper(I) bromide;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; toluene; mineral oil; benzene;
9.1: |Wittig Olefination;
DOI:10.1039/c4ob00323c
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: dmap; triethylamine / dichloromethane / 0 - 20 °C
2.1: toluene-4-sulfonic acid / methanol / 0 - 20 °C
3.1: potassium carbonate / methanol / 2 h / 0 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C
4.2: 0 - 20 °C
5.1: copper(I) bromide / tetrahydrofuran; diethyl ether / 0 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 0 - 20 °C
7.1: ozone / dichloromethane / -78 °C / Inert atmosphere
8.1: benzene / 2 h / 20 °C
9.1: diisobutylaluminium hydride / dichloromethane; toluene / 20 °C / Cooling
With
dmap; sodium hydride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; ozone; triethylamine; N-ethyl-N,N-diisopropylamine; copper(I) bromide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; mineral oil; benzene;
8.1: |Wittig Olefination;
DOI:10.1039/c4ob00323c
