(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-N,N-dimethyl-4-(2-methylphenyl)octahydro-2H-isoindole-2-carboxamide

Base Information

Chemical Name:(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-N,N-dimethyl-4-(2-methylphenyl)octahydro-2H-isoindole-2-carboxamide
CAS No.:1070763-65-3
Molecular Formula:C₂₈H₃₂F₆N₂O₃
Molecular Weight:558.564
Hs Code.:

Synonyms:(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-N,N-dimethyl-4-(2-methylphenyl)octahydro-2H-isoindole-2-carboxamide

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Chemical Property of (3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-N,N-dimethyl-4-(2-methylphenyl)octahydro-2H-isoindole-2-carboxamide

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Technology Process of (3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-N,N-dimethyl-4-(2-methylphenyl)octahydro-2H-isoindole-2-carboxamide

There total 5 articles about (3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-N,N-dimethyl-4-(2-methylphenyl)octahydro-2H-isoindole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₄F₆N₂O₄

: 1070763-65-3
(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-N,N-dimethyl-4-(2-methylphenyl)octahydro-2H-isoindole-2-carboxamide

Guidance literature:: With sodium hydroxide; In methanol; at 50 ℃; for 1h;

Reference yield:

: 1070764-31-6
(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-(acetohydroxyethoxy)}-4-(2-methylphenyl)octahydro-1H-isoindole

: 1070763-65-3
(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-N,N-dimethyl-4-(2-methylphenyl)octahydro-2H-isoindole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 1 h / 20 °C

2: sodium hydroxide / methanol / 1 h / 50 °C

With dmap; sodium hydroxide; triethylamine; In methanol; dichloromethane;

Reference yield:

: 1070764-30-5
tert-butyl (3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-(acetohydroxyethoxy)}-4-(2-methylphenyl)octahydro-2H-isoindole-2-carboxylate

: 1070763-65-3
(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-N,N-dimethyl-4-(2-methylphenyl)octahydro-2H-isoindole-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h

2: dmap; triethylamine / dichloromethane / 1 h / 20 °C

3: sodium hydroxide / methanol / 1 h / 50 °C

With hydrogenchloride; dmap; sodium hydroxide; triethylamine; In 1,4-dioxane; methanol; dichloromethane;