N-(1-{4-[(hydroxyamino)carbonyl]phenyl}-2-methylpropyl)adamantane-1-carboxamide

Base Information

Chemical Name:N-(1-{4-[(hydroxyamino)carbonyl]phenyl}-2-methylpropyl)adamantane-1-carboxamide
CAS No.:1332889-86-7
Molecular Formula:C₂₂H₃₀N₂O₃
Molecular Weight:370.492
Hs Code.:

Synonyms:N-(1-{4-[(hydroxyamino)carbonyl]phenyl}-2-methylpropyl)adamantane-1-carboxamide

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Chemical Property of N-(1-{4-[(hydroxyamino)carbonyl]phenyl}-2-methylpropyl)adamantane-1-carboxamide

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Technology Process of N-(1-{4-[(hydroxyamino)carbonyl]phenyl}-2-methylpropyl)adamantane-1-carboxamide

There total 5 articles about N-(1-{4-[(hydroxyamino)carbonyl]phenyl}-2-methylpropyl)adamantane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332894-75-3
ethyl 4-{1-[(adamantan-1-ylcarbonyl)amino]-2-methylpropyl}benzoate

: 1332889-86-7
N-(1-{4-[(hydroxyamino)carbonyl]phenyl}-2-methylpropyl)adamantane-1-carboxamide

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 80 ℃; for 1h;

Reference yield:

: 131379-16-3
4-(ethoxycarbonyl)phenylzinc iodide

: 1332889-86-7
N-(1-{4-[(hydroxyamino)carbonyl]phenyl}-2-methylpropyl)adamantane-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 °C

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 2 h / 36 °C

3.1: zinc; acetic acid / 1 h / 20 °C

3.2: 0.17 h / 20 °C

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 16 h / 20 °C

5.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 1 h / 80 °C

With hydroxylamine hydrochloride; sodium acetate; acetic acid; triethylamine; HATU; potassium hydroxide; zinc; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1332894-72-0
ethyl 4-(1-amino-2-methylpropyl)benzoate

: 1332889-86-7
N-(1-{4-[(hydroxyamino)carbonyl]phenyl}-2-methylpropyl)adamantane-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 16 h / 20 °C

2.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 1 h / 80 °C

With hydroxylamine hydrochloride; triethylamine; HATU; potassium hydroxide; In methanol; N,N-dimethyl-formamide;