bis(1,1-dimethylethyl) {3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate

Base Information

Chemical Name:bis(1,1-dimethylethyl) {3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate
CAS No.:1093262-77-1
Molecular Formula:C₂₃H₂₄BrClFNO₇
Molecular Weight:560.801
Hs Code.:

Synonyms:bis(1,1-dimethylethyl) {3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate

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Chemical Property of bis(1,1-dimethylethyl) {3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate

Chemical Property:

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Technology Process of bis(1,1-dimethylethyl) {3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate

There total 1 articles about bis(1,1-dimethylethyl) {3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 541-16-2
t-butyl malonate

: 1093267-98-1
2-[(3-bromo-5-chlorophenyl)oxy]-3,4-difluoro-1-nitrobenzene

: 1093262-77-1
bis(1,1-dimethylethyl) {3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate

Guidance literature:: t-butyl malonate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

2-[(3-bromo-5-chlorophenyl)oxy]-3,4-difluoro-1-nitrobenzene; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1093262-77-1
bis(1,1-dimethylethyl) {3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate

: 1093262-79-3
{3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}acetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 40 ℃; for 3h;

Reference yield:

: 1093262-77-1
bis(1,1-dimethylethyl) {3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate

: 1093256-26-8
4-chloro-N-[(4-chloro-3-{[3-chloro-5-(cyclopropylethynyl)phenyl]oxy}-2-fluorophenyl)methyl]-2-ethyl-1H-imidazole-5-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 40 °C

2: copper(I) oxide / acetonitrile / 3 h / Reflux

3: sodium dithionite / tetrahydrofuran; water / 16 h / 40 °C

4: tert.-butylnitrite; copper dichloride / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

5: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 6 h / 90 °C / Inert atmosphere

6: ammonia / methanol; dichloromethane / 4 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

8: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 90 °C

With copper(I) oxide; N-Bromosuccinimide; copper(l) iodide; tert.-butylnitrite; sodium dithionite; 2,2'-azobis(isobutyronitrile); ammonia; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; copper dichloride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;