(1S,2R)-2-((2-Bromo-benzyl)-{5-[(2-bromo-benzyl)-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-amino]-3-triisopropylsilanyloxymethyl-pentyl}-amino)-1-phenyl-propan-1-ol

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Chemical Name:(1S,2R)-2-((2-Bromo-benzyl)-{5-[(2-bromo-benzyl)-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-amino]-3-triisopropylsilanyloxymethyl-pentyl}-amino)-1-phenyl-propan-1-ol
CAS No.:796842-98-3
Molecular Formula:C₄₇H₆₆Br₂N₂O₃Si
Molecular Weight:894.946
Hs Code.:

(1S,2R)-2-((2-Bromo-benzyl)-{5-[(2-bromo-benzyl)-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-amino]-3-triisopropylsilanyloxymethyl-pentyl}-amino)-1-phenyl-propan-1-ol

Synonyms:(1S,2R)-2-((2-Bromo-benzyl)-{5-[(2-bromo-benzyl)-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-amino]-3-triisopropylsilanyloxymethyl-pentyl}-amino)-1-phenyl-propan-1-ol

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Chemical Property of (1S,2R)-2-((2-Bromo-benzyl)-{5-[(2-bromo-benzyl)-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-amino]-3-triisopropylsilanyloxymethyl-pentyl}-amino)-1-phenyl-propan-1-ol

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Technology Process of (1S,2R)-2-((2-Bromo-benzyl)-{5-[(2-bromo-benzyl)-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-amino]-3-triisopropylsilanyloxymethyl-pentyl}-amino)-1-phenyl-propan-1-ol

There total 1 articles about (1S,2R)-2-((2-Bromo-benzyl)-{5-[(2-bromo-benzyl)-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-amino]-3-triisopropylsilanyloxymethyl-pentyl}-amino)-1-phenyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 171023-18-0
3-cyclopentenemethanol triisopropylsilyl ether

: 393109-60-9
(1S,2R)-N-(2-bromobenzyl)norephedrine

: 796842-98-3
(1S,2R)-2-((2-Bromo-benzyl)-{5-[(2-bromo-benzyl)-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-amino]-3-triisopropylsilanyloxymethyl-pentyl}-amino)-1-phenyl-propan-1-ol

Guidance literature:: 3-cyclopentenemethanol triisopropylsilyl ether; With sodium hydrogencarbonate; ozone; In methanol; dichloromethane; at -78 ℃; for 0.0833333h;

With dimethylsulfide; In methanol; dichloromethane; at -78 - 20 ℃;

(1S,2R)-N-(2-bromobenzyl)norephedrine; With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 24h;
DOI:10.1021/ol048273c

Reference yield: 90.0%

: 95-56-7
2-hydroxybromobenzene

: 796842-98-3
(1S,2R)-2-((2-Bromo-benzyl)-{5-[(2-bromo-benzyl)-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-amino]-3-triisopropylsilanyloxymethyl-pentyl}-amino)-1-phenyl-propan-1-ol

: 796842-99-4
N,N'-bis-(2-bromo-benzyl)-N,N'-bis-[2-(2-bromo-phenoxy)-1-methyl-2-phenyl-ethyl]-3-triisopropylsilanyloxymethyl-pentane-1,5-diamine

Guidance literature:: With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In benzene; at 20 ℃; for 12h;
DOI:10.1021/ol048273c

Reference yield:

: 796842-98-3
(1S,2R)-2-((2-Bromo-benzyl)-{5-[(2-bromo-benzyl)-((1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-amino]-3-triisopropylsilanyloxymethyl-pentyl}-amino)-1-phenyl-propan-1-ol

: C₅₉H₇₂N₂O₃Si

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / PPh₃; 1,1'-azodicarbonyldipiperidine / benzene / 12 h / 20 °C

2.1: 2MeTHF; t-BuLi / pentane / 0.5 h / -78 °C

2.2: CuCN*2LiBr / pentane / 2 h / -78 - -40 °C

2.3: 59 percent / m-dinitrobenzene / pentane / 12 h / -40 - 20 °C

With tert.-butyl lithium; triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In pentane; benzene; 1.1: Mitsunobu reaction;
DOI:10.1021/ol048273c