4-[β-2-(2-fluoroethoxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonamide

Base Information

• Chemical Name: 4-[β-2-(2-fluoroethoxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonamide
• CAS No.: 334652-79-8
• Molecular Formula: C₁₇H₁₈ClFN₂O₄S
• Molecular Weight: 400.858

Synonyms:4-[β-2-(2-fluoroethoxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonamide

Chemical Property of 4-[β-2-(2-fluoroethoxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonamide

Chemical Property:

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Technology Process of 4-[β-2-(2-fluoroethoxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonamide

There total 3 articles about 4-[β-2-(2-fluoroethoxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

5-chloro-2-(2-fluoroethoxy)benzoic acid (334652-74-3) + 4-(2-aminoethyl)benzenesulfonamide (35303-76-5) → 4-[β-2-(2-fluoroethoxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonamide (334652-79-8)

Guidance literature:

5-chloro-2-(2-fluoroethoxy)benzoic acid; With chloroformic acid ethyl ester; triethylamine; In acetone; at 0 ℃; for 0.333333h;

4-(2-aminoethyl)benzenesulfonamide; With triethylamine; In acetone; at 0 - 20 ℃;

DOI:10.1002/jlcr.438

Reference yield:

5-chloro-2-hydroxybenzoic acid (321-14-2) → 4-[β-2-(2-fluoroethoxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonamide (334652-79-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH

2: NaOH

With sodium hydroxide; sodium hydride;

DOI:10.1002/jlcr.436

Reference yield:

2-fluoroethyl 5-chloro-2-(2-fluoroethoxy)benzoate (334652-76-5) → 4-[β-2-(2-fluoroethoxy-5-chlorobenzene carboxamido)ethyl]benzene-sulfonamide (334652-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH

With sodium hydroxide;

DOI:10.1002/jlcr.436

upstream raw materials:

5-chloro-2-(2-fluoroethoxy)benzoic acid

4-(2-aminoethyl)benzenesulfonamide

5-chloro-2-hydroxybenzoic acid

2-fluoroethyl 5-chloro-2-(2-fluoroethoxy)benzoate

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