2-nitro-3,4,5,6-tetrabromoanisole

Base Information

• Chemical Name: 2-nitro-3,4,5,6-tetrabromoanisole
• CAS No.: 6161-58-6
• Molecular Formula: C₇H₃Br₄NO₃
• Molecular Weight: 468.722
• Mol file: 6161-58-6.mol

Synonyms:2-nitro-3,4,5,6-tetrabromoanisole

Chemical Property of 2-nitro-3,4,5,6-tetrabromoanisole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-nitro-3,4,5,6-tetrabromoanisole

There total 6 articles about 2-nitro-3,4,5,6-tetrabromoanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,3,4,5-tetrabromoanisole (6161-61-1) → 2-nitro-3,4,5,6-tetrabromoanisole (6161-58-6)

Guidance literature:

With nitric acid; In acetic anhydride; at 35 - 40 ℃; for 1.3h;

DOI:10.1007/BF01151297

Reference yield:

2,4-dibromo-6-nitrophenol (15969-09-2) → 2-nitro-3,4,5,6-tetrabromoanisole (6161-58-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol / 20 °C

1.2: 1.25 h

2.1: hydrogenchloride; tin(ll) chloride / acetic acid / 6 h / 70 - 80 °C

3.1: hydrogenchloride; tin(ll) chloride / acetic acid / 6 h / 70 - 80 °C

3.2: 1.5 h / 50 °C

4.1: hydrogenchloride; tin(ll) chloride / acetic acid / 6 h / 70 - 80 °C

4.2: 1.5 h / 50 °C

5.1: nitric acid / acetic anhydride / 0.03 h

With hydrogenchloride; nitric acid; tin(ll) chloride; potassium hydroxide; In ethanol; acetic anhydride; acetic acid;

DOI:10.1134/S1070428012080064

Reference yield:

3,4,5,6-tetrabromo-2-methoxyaniline → 2-nitro-3,4,5,6-tetrabromoanisole (6161-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; tin(ll) chloride / acetic acid / 6 h / 70 - 80 °C

1.2: 1.5 h / 50 °C

2.1: nitric acid / acetic anhydride / 0.03 h

With hydrogenchloride; nitric acid; tin(ll) chloride; In acetic anhydride; acetic acid;

DOI:10.1134/S1070428012080064

upstream raw materials:

2,3,4,5-tetrabromoanisole

pentabromonitrobenzene

sodium methylate

4-methoxy-2-nitroacetanilide

Downstream raw materials:

2,3,4,5-tetrabromo-6-nitrophenol

Refernces

• 1、 Shishkin, V. N.,Lapin, K. K.,Shabarina, S. A.,Butin, K. P.. "Regioselectivity of methoxydebromination of substituted pentabromobenzenes C6Br5X in pyridine". . p. 1715 - 1719. Retrieved 2007/10/03.