cyclopentyl (2S)-cyclohexyl{[3-(4-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}phenoxy)propyl]amino}acetate

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Chemical Name:cyclopentyl (2S)-cyclohexyl{[3-(4-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}phenoxy)propyl]amino}acetate
CAS No.:1018674-36-6
Molecular Formula:C₃₁H₄₈N₂O₆
Molecular Weight:544.732
Hs Code.:

Synonyms:cyclopentyl (2S)-cyclohexyl{[3-(4-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}phenoxy)propyl]amino}acetate

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Chemical Property of cyclopentyl (2S)-cyclohexyl{[3-(4-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}phenoxy)propyl]amino}acetate

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Technology Process of cyclopentyl (2S)-cyclohexyl{[3-(4-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}phenoxy)propyl]amino}acetate

There total 6 articles about cyclopentyl (2S)-cyclohexyl{[3-(4-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}phenoxy)propyl]amino}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 956928-36-2
cyclopentyl (2S)-amino(cyclohexyl)acetate hydrochloride

: 1018674-35-5
(2E)-3-[4-(3-bromopropoxy)phenyl]-N-(1-isobutoxyethoxy)acrylamide

: 1018674-36-6
cyclopentyl (2S)-cyclohexyl{[3-(4-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}phenoxy)propyl]amino}acetate

Guidance literature:: With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 70 - 80 ℃; for 28.5h;

Reference yield:

: 860216-27-9
O-(1-isobutoxyethyl)hydroxylamine

: 1018674-36-6
cyclopentyl (2S)-cyclohexyl{[3-(4-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}phenoxy)propyl]amino}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.75 h / 20 °C

1.2: 1.5 h / 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 1 h / 20 °C

3.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 28.5 h / 70 - 80 °C

With di-isopropyl azodicarboxylate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 914604-31-2
(S)-tert-butoxycarbonylamino-cyclohexyl-acetic acid cyclopentyl ester

: 1018674-36-6
cyclopentyl (2S)-cyclohexyl{[3-(4-{(1E)-3-[(1-isobutoxyethoxy)amino]-3-oxoprop-1-en-1-yl}phenoxy)propyl]amino}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 24 h / 20 °C

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 28.5 h / 70 - 80 °C

With hydrogenchloride; potassium carbonate; sodium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;