(-)-(2S,S_s)-3,3-difluoro-3-phenyl-2-(N-benzyloxycarbonyl)aminopropyl-(1-naphthyl)sulfoxide

Base Information

• Chemical Name: (-)-(2S,S_s)-3,3-difluoro-3-phenyl-2-(N-benzyloxycarbonyl)aminopropyl-(1-naphthyl)sulfoxide
• CAS No.: 1020850-64-9
• Molecular Formula: C₂₇H₂₃F₂NO₃S
• Molecular Weight: 479.547

Synonyms:(-)-(2S,S_s)-3,3-difluoro-3-phenyl-2-(N-benzyloxycarbonyl)aminopropyl-(1-naphthyl)sulfoxide

Chemical Property of (-)-(2S,S_s)-3,3-difluoro-3-phenyl-2-(N-benzyloxycarbonyl)aminopropyl-(1-naphthyl)sulfoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(2S,S_s)-3,3-difluoro-3-phenyl-2-(N-benzyloxycarbonyl)aminopropyl-(1-naphthyl)sulfoxide

There total 5 articles about (-)-(2S,S_s)-3,3-difluoro-3-phenyl-2-(N-benzyloxycarbonyl)aminopropyl-(1-naphthyl)sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C19H17F2NOS + benzyl chloroformate (501-53-1,94274-21-2) → (-)-(2S,Ss)-3,3-difluoro-3-phenyl-2-(N-benzyloxycarbonyl)aminopropyl-(1-naphthyl)sulfoxide (1020850-64-9)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.jfluchem.2007.03.001

Reference yield:

(-)-(2S,Ss)-3,3-difluoro-3-phenyl-2-[N-(p-methoxyphenyl)]aminopropyl-(1-naphthyl)sulfoxide (1020850-63-8) → (-)-(2S,Ss)-3,3-difluoro-3-phenyl-2-(N-benzyloxycarbonyl)aminopropyl-(1-naphthyl)sulfoxide (1020850-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / CAN; H₂O / acetonitrile / 20 °C

2: 92 percent / aq. K₂CO₃ / dioxane / 20 °C

With ammonium cerium(IV) nitrate; water; potassium carbonate; In 1,4-dioxane; acetonitrile;

DOI:10.1016/j.jfluchem.2007.03.001

Reference yield:

(+)-(Ss)-{3,3-difluoro-3-phenyl-2-[N-(p-methoxyphenyl)imino]propyl}-(1-naphthyl)sulfoxide (1020850-62-7) → (-)-(2S,Ss)-3,3-difluoro-3-phenyl-2-(N-benzyloxycarbonyl)aminopropyl-(1-naphthyl)sulfoxide (1020850-64-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / NaBH₄ / tetrahydrofuran; methanol / 5 h / -20 °C

2: 78 percent / CAN; H₂O / acetonitrile / 20 °C

3: 92 percent / aq. K₂CO₃ / dioxane / 20 °C

With sodium tetrahydroborate; ammonium cerium(IV) nitrate; water; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitrile;

DOI:10.1016/j.jfluchem.2007.03.001

upstream raw materials:

benzyl chloroformate

(+)-(S_s)-{3,3-difluoro-3-phenyl-2-[N-(p-methoxyphenyl)imino]propyl}-(1-naphthyl)sulfoxide

(-)-(2S,S_s)-3,3-difluoro-3-phenyl-2-[N-(p-methoxyphenyl)]aminopropyl-(1-naphthyl)sulfoxide

(S)-(-)-methyl 1-naphthyl sulfoxide

Downstream raw materials:

(-)-(2R)-2-(N-benzyloxycarbonyl)amino-3,3-difluoro-3-phenylpropanol

(-)-(4R)-4-(phenyldifluoromethyl)-oxazolidin-2-one

(-)-(4R)-4-(phenyldifluoromethyl)-3-propionyl-oxazolidin-2-one

(4R)-4-(phenyldifluoromethyl)-N-(2S,3R)-(3-hydroxy-2,4-dimethyl-pentanoyl)-1,3-oxazolidin-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1020850-64-9 (-)-(2S,S_s)-3,3-difluoro-3-phenyl-2-(N-benzyloxycarbonyl)aminopropyl-(1-naphthyl)sulfoxide

Send

Send

Metric Ton KG G Pound L ML

Send

Send